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首页> 外文期刊>The journal of maternal-fetal & neonatal medicine >Renal safety of Non Steroidal Anti Inflammatory Drugs (NSAIDs) in the pharmacologic treatment of patent ductus arteriosus.
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Renal safety of Non Steroidal Anti Inflammatory Drugs (NSAIDs) in the pharmacologic treatment of patent ductus arteriosus.

机译：非甾体抗炎药（NSAIDs）在动脉导管未闭的药物治疗中的肾脏安全性。

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摘要

Patent ductus arteriosus (PDA) often complicates the clinical course of neonates born prematurely and increases their short- and long-term morbidity. Treatment of PDA remains an ongoing debate among neonatologists for various issues such as the timing, the criteria and the methods for its closure. Non steroidal anti inflammatory drugs have been used as the standard pharmacological treatment for PDA. Indomethacin was the first one to be used. Its use though, waned due recognition of renal cerebral and gastrointestinal complications associated with the administration of this drug. Ibuprofen has emerged in clinical practice, as it has been reported to have lower nephrotoxicity. This review will examine existing data in the literature on the early- and long-term nephrotoxicity associated with the two drugs and will discuss present and future directions the management and prevention of this condition.
机译：动脉导管未闭（PDA）通常使早产新生儿的临床过程复杂化，并增加其短期和长期发病率。 PDA的治疗仍然是新生儿学家之间有关诸如时机，标准和关闭方法等各种问题的持续辩论。非甾体抗炎药已被用作PDA的标准药物治疗方法。消炎痛是第一个使用的。但是，它的使用削弱了与该药物给药有关的肾脑和胃肠道并发症的应有认识。布洛芬已经在临床实践中出现，因为据报道其肾毒性较低。这篇综述将检查文献中与这两种药物相关的早期和长期肾毒性的现有数据，并将讨论目前和将来对该病的管理和预防方向。

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