...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The journal of maternal-fetal & neonatal medicine >Longitudinal assessment of maternal-fetal Doppler parameters and maternal plasma level of matrix metalloproteinases 2 and 9
【24h】

Longitudinal assessment of maternal-fetal Doppler parameters and maternal plasma level of matrix metalloproteinases 2 and 9

机译：母胎多普勒参数和母体血浆金属蛋白酶2和9的血浆水平的纵向评估

获取原文
获取原文并翻译 | 示例
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Objective: To assess the behavior as well as the comparison between maternal circulating level of biochemical markers (matrix metalloproteinases - MMP-9 and MMP-2) and maternal-fetal Doppler parameters in all three trimesters of pregnancy.Methods: We performed a prospective longitudinal study with 33 healthy pregnant women in three periods of pregnancy: A1 (12w0-14w6d), A2 (22w0d-24w6d) and A3 (34w0d and 36w6d). The following maternal Doppler parameters were assessed: mean pulsatility index (PI) uterine artery, resistance index (RI) umbilical artery and RI middle cerebral artery. The maternal plasma concentrations of MMP-2 and MMP-9 were determined by enzyme immunoassay (ELISA). To compare two (A2 and A3) and three assessments (A1, A2 and A3), we used the paired Student t test and linear regression, respectively. To compare the biomechanical markers and maternal-fetal Doppler parameter, we used the Spearman correlation coefficient ().Results: We observed a significant decrease of PI uterine artery Doppler over the three trimesters of pregnancy (p<0.01) and RI umbilical artery Doppler overt second to three trimester of pregnancy (p<0.05). We did not observe significant difference in the maternal plasma level of MMP-2 and MMP-9 between the three trimesters. We did not also observe significant correlation between biochemical markers and maternal-fetal Doppler parameters.Conclusion: Maternal circulating level of MMPs did not modify throughout pregnancy and it did not show correlation with maternal-fetal Doppler parameters.
机译：目的：评估在怀孕的所有三个月中，孕妇的生化指标（基质金属蛋白酶-MMP-9和MMP-2）的行为以及其循环水平与母胎多普勒参数之间的比较以及方法之间的比较。对33名健康孕妇在三个怀孕阶段进行的研究：A1（12w0-14w6d），A2（22w0d-24w6d）和A3（34w0d和36w6d）。评估了以下孕妇多普勒参数：平均搏动指数（PI）子宫动脉，抵抗指数（RI）脐动脉和RI中脑动脉。母体血浆MMP-2和MMP-9的浓度通过酶联免疫法（ELISA）测定。为了比较两个评估（A2和A3）和三个评估（A1，A2和A3），我们分别使用了成对的Student t检验和线性回归。为了比较生物力学指标和母胎多普勒参数，我们使用了Spearman相关系数（）。结果：我们观察到妊娠三个月期间PI子宫动脉多普勒显着降低（p <0.01）和RI脐动脉多普勒显着降低妊娠第二至三个月（p <0.05）。在三个三个月之间，我们没有观察到母亲血浆中MMP-2和MMP-9的显着差异。我们也没有观察到生化标志物与母胎多普勒参数之间的显着相关性。结论：孕妇的MMPs循环水平在整个妊娠期间没有改变，并且与母胎多普勒参数没有相关性。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号