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首页> 外文期刊>The journal of maternal-fetal & neonatal medicine >Vancomycin-resistant enterococci colonization in a neonatal intensive care unit: who will be infected?
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Vancomycin-resistant enterococci colonization in a neonatal intensive care unit: who will be infected?

机译：新生儿重症监护室中耐万古霉素的肠球菌定植：谁将被感染？

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摘要

Objective: To determine the incidence of vancomycin-resistant enterococcus (VRE) colonization in our neonatal intensive care unit (NICU) over five-year period, rate of progression to VRE infection and associated risk factors.Methods: A retrospective analysis of a prospective surveillance for VRE colonization and health care-associated infections was made. Contact precautions were taken against colonization, although the application varied over the years due to repairs in the unit.Results: VRE rectal colonization was detected in 200/1671 neonates (12%) admitted to NICU. It showed great interannual variability from 1.9% to 30.3%. Sytemic VRE infection developed in 6/200 VRE-colonized patients (3%) within a median of 9 days (range: 3-58 days). The risk factors for VRE infection development identified in the univariate analysis were long hospital stay (30 days), necrotizing enterocolitis, surgical procedure, extraventricular drainage, receipt of amphotericin B and receipt of glycopeptides after detection of VRE colonization. Crude in-hospital mortality was higher in neonates who developed a systemic VRE infection (p<0.001).Conclusion: Maintaining physical conditions in the unit favorable for infection control and rational use of antibiotics are essential in the control of VRE colonization and resultant infections. Special attention should be directed to VRE-colonized babies carrying the risk factors.
机译：目的：确定五年期新生儿重症监护病房（NICU）中耐万古霉素肠球菌（VRE）定植的发生率，进展为VRE感染的速度以及相关的危险因素。方法：前瞻性监测的回顾性分析进行了VRE定植和与卫生保健相关的感染。尽管由于单位的维修，多年来的应用情况有所不同，但仍采取了预防接触的预防措施。结果：在新生儿重症监护病房（NICU）的200/1671名新生儿中检测到VRE直肠定植。它显示出从1.9％到30.3％的较大年际变化。 Sytemic VRE感染在中位数9天（范围：3-58天）内发生在6/200 VRE殖民化患者中（3％）。在单变量分析中确定的VRE感染发展的危险因素是住院时间长（30天），坏死性小肠结肠炎，外科手术，脑室引流，接受两性霉素B和检测到VRE菌落后接受糖肽。发生全身性VRE感染的新生儿的院内死亡率较高（p <0.001）。结论：保持单位的身体状况有利于感染的控制和合理使用抗生素对于控制VRE的定殖和由此引起的感染至关重要。应特别注意携带有危险因素的VRE定植的婴儿。

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