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首页> 外文期刊>The Journal of maternal-fetal medicine >Antepartum, transabdominal near infrared spectroscopy: feasibility of measuring photon migration through the fetal head in utero.
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Antepartum, transabdominal near infrared spectroscopy: feasibility of measuring photon migration through the fetal head in utero.

机译：产前，经腹近红外光谱：测量通过子宫胎头的光子迁移的可行性。

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OBJECTIVE: We report the feasibility of measuring photon migration through the fetal head in utero using antepartum, transabdominal, near infrared (NIR) spectroscopy. METHODS: We developed a continuous wave (CW) spectrometer that incorporates a halogen light source, silicon photodetectors, and a differential processing circuit for antepartum, transabdominal, NIR spectroscopy. By placement of the light source and photodetector on the midline of the maternal abdomen above the fetal head at a separation (approximately 10 cm) large enough for the light to propagate through maternal and fetal tissues via multiple scattering events before being detected at the surface and the use of filtered illumination and detection at wavelengths (760 nm, 850 nm), which coincide with the absorption bands of oxygenated and deoxygenated hemoglobin in the NIR window, we performed studies to evaluate whether antepartum, transabdominal NIR spectroscopy can measure photon migration through the fetal head in utero. RESULTS: The results demonstrate that the CW spectrometer we developed can be employed to make NIR measurements from the maternal abdomen at a 10 cm source-detector separation, with an excellent signal-to-noise ratio. Furthermore, a variety of antepartum, transabdominal NIR measurements that we performed on patients undergoing a routine nonstress test demonstrate the feasibility of measuring photon migration through the fetal head in utero. CONCLUSIONS: Preliminary assessment of transabdominal NIR spectroscopy suggests that this technique can enable photon migration through the fetal head in utero. This is an important step towards the development of this technique for measuring and quantifying fetal cerebral blood oxygenation in utero.
机译：目的：我们报告使用产前，经腹，近红外（NIR）光谱测量子宫内光子通过胎儿头的迁移的可行性。方法：我们开发了一种连续波（CW）光谱仪，该光谱仪结合了卤素光源，硅光电探测器以及用于产前，经腹，近红外光谱的差分处理电路。通过将光源和光电探测器放置在胎儿头部上方母体腹部的中线上，并保持足够大的距离（大约10厘米），以使光能够通过多次散射事件在母体和胎儿组织中传播，然后再在表面和表面进行检测通过使用过滤后的照明和检测（760 nm，850 nm）波长与NIR窗口中含氧和脱氧血红蛋白的吸收带一致，我们进行了研究以评估产前，经腹NIR光谱是否可以测量通过胎儿在​​子宫内。结果：结果表明，我们开发的连续波光谱仪可用于以10 cm的源-检测器间隔从孕妇腹部进行NIR测量，并具有出色的信噪比。此外，我们对接受常规无压力测试的患者进行的各种产前，经腹NIR测量证明了通过子宫内胎儿头测量光子迁移的可行性。结论：经腹部近红外光谱的初步评估表明，该技术可以使光子通过子宫内的胎儿头部迁移。这是开发用于测量和定量子宫内胎儿脑部血氧合的技术的重要一步。

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