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Monitoring the Response of Chemotherapy on Breast Cancer Tumors by Photon Migration Spectroscopy

机译：用光子迁移光谱法监测乳腺癌肿瘤化疗的疗效

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Optimal management of patients with locally advanced breast cancer (LABC) remains a complex therapeutic problem. The optimal intensity and duration of the neoadjuvant chemotherapy regiment for LABC still remains controversial due to the difficulty of evaluating response to the treatment. The goal of this project is to use Photon Migration Spectroscopy (PMS) as a new modality to monitor the response of breast tumor to neoadjuvant chemotherapy. We measured 29 patients and PMS showed excellent sensitivity to the crucial early functional changes in breast tissue subjected to neoadjuvant chemotherapy. We defined a novel new 'Optical Index' which incorporates all the optical parameters into a single easy to understand value which better describes the response of the tumor to the neoadjuvant chemotherapy. By using PMS and the optical index we are able to distinguish between subjects responding to neoadjuvant chemotherapy versus the non responders. Conclusion: By using Photon Migration Spectroscopy we have been successful in monitoring the response of breast cancer to neoadjuvant chemotherapy and identifying responders vs non-responders.

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