• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The Journal of maternal-fetal medicine >Efficacy of azithromycin in reducing lower genital Ureaplasma urealyticum colonization in women at risk for preterm delivery.
【24h】

Efficacy of azithromycin in reducing lower genital Ureaplasma urealyticum colonization in women at risk for preterm delivery.

机译：阿奇霉素在减少早产风险妇女中降低下生殖器解脲支原体定植的功效。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

OBJECTIVE: The purpose of this study was to determine if azithromycin is effective in reducing lower genital colonization of Ureaplasma urealyticum in women with preterm labor or preterm premature rupture of membranes (PROM). METHODS: A randomized, double-blinded, placebo-controlled prospective study of 60 pregnancies was carried out between 22 and 34 weeks. Genital mycoplasma cultures were performed at the time of admission. Patients were randomized to receive either a single dose of azithromycin (four 250 mg capsules) or a placebo in addition to prophylactic intravenous ampicillin. Repeat cultures were done on undelivered patients 7 days after enrollment. The study had power to detect a 50% decrease in colonization. RESULTS: Overall, lower genital colonization was 47/59 (79.7%) for U. urealyticum. Seven days after enrollment, U. urealyticum was isolated in 14/15 (93.3%) of the azithromycin-treated cases and in 11/14 (78.6%) of the controls (RR = 1.19, 95% CI = 0.88-1.61). Vertical transmission of U. urealyticum was 3/15 (20%) in the azithromycin-treated cases and 5/10 (50%) for the controls (RR = 0.40, 95%, CI = 0.12-1.31). CONCLUSION: These data suggests that a single 1 g dose of azithromycin is ineffective in reducing lower genital colonization with U. urealyticum.
机译：目的：本研究的目的是确定阿奇霉素是否能有效减少早产或早产胎膜早破（PROM）妇女的解脲支原体下生殖器定植。方法：在22至34周之间进行了一项随机，双盲，安慰剂对照的60例妊娠的前瞻性研究。入院时进行生殖道支原体培养。除预防性静脉内使用氨苄青霉素外，患者随机接受单剂量阿奇霉素（四个250毫克胶囊）或安慰剂。入选后7天，对未分娩的患者进行重复培养。这项研究有能力检测到殖民地减少50％。结果：总体而言，解脲支原体的下生殖器定植率为47/59（79.7％）。入选后第7天，在14/15（93.3％）的阿奇霉素治疗病例和11/14（78.6％）的对照中分离出解脲脲原体（RR = 1.19，95％CI = 0.88-1.61）。解脲脲原体的垂直传播在阿奇霉素治疗的病例中为3/15（20％），在对照组中为5/10（50％）（RR = 0.40，95％，CI = 0.12-1.31）。结论：这些数据表明，单剂量1 g阿奇霉素在减少解脲支原体下生殖器定植方面是无效的。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号