...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Chinese journal of digestive diseases >Correlation between a gene polymorphism of tumor necrosis factor and inflammatory bowel disease.
【24h】

Correlation between a gene polymorphism of tumor necrosis factor and inflammatory bowel disease.

机译：肿瘤坏死因子基因多态性与炎性肠病的相关性。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

OBJECTIVES: To analyze polymorphism of the tumor necrosis factor (TNF) gene in inflammatory bowel disease (IBD) patients from the Han Chinese ethnic group, and to investigate the role of polymorphism in the pathogenesis of IBD. METHODS: Polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) techniques were used to analyze gene polymorphisms in the TNF-alpha and TNF-beta genes in 131 patients with IBD. RESULTS: The genotype frequency and allelic frequency of TNF-alpha-308 in patients with ulcerative colitis (UC) were 15.5% and 8.7%, respectively, significantly higher than the control population (4.1% and 2.0%, respectively; P < 0.001). There was no significant difference between patients with Crohn's disease (CD) and the normal population with regard to the genotype frequency and allelic frequency of TNF-alpha-308, and neither were there any differences with regard to TNF-beta+252 in patients with IBD (UC and CD) and the normal population. The TNF-alpha-308 polymorphism and the TNF-beta+252 loci did not correlate with age, gender, disease activity or lesion site for IBD patients. CONCLUSIONS: The TNF-alpha-308 allele may be related to susceptibility to UC. The TNF-alpha-308 gene polymorphism is not involved in pathogenesis of CD. No correlation was found between the TNF-beta+252 polymorphism and IBD. Polymorphisms of the TNF-alpha-308 and TNF-beta+252 loci do not correlate with age, gender, disease activity or lesion site.
机译：目的：分析汉族人群炎症性肠病（IBD）患者肿瘤坏死因子（TNF）基因的多态性，探讨多态性在IBD发病机制中的作用。方法：采用聚合酶链反应（PCR）和限制性片段长度多态性（RFLP）技术分析131例IBD患者TNF-α和TNF-β基因的基因多态性。结果：溃疡性结肠炎（UC）患者的TNF-α-308基因型频率和等位基因频率分别为15.5％和8.7％，显着高于对照组（分别为4.1％和2.0％; P <0.001） 。克罗恩病（CD）患者与正常人群在TNF-alpha-308的基因型频率和等位基因频率方面无显着差异，在TNF-beta + 252的患者中，TNF-beta + 252也无任何差异IBD（UC和CD）和正常人群。 TNF-alpha-308多态性和TNF-beta + 252基因座与IBD患者的年龄，性别，疾病活动或病变部位无关。结论：TNF-α-308等位基因可能与UC易感性有关。 TNF-alpha-308基因多态性不参与CD的发病机制。在TNF-beta + 252多态性与IBD之间未发现相关性。 TNF-alpha-308和TNF-beta + 252基因座的多态性与年龄，性别，疾病活动性或病变部位无关。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号