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首页> 外文期刊>The Journal of hospital infection >Risk factors for multidrug-resistant Pseudomonas aeruginosa nosocomial infection.
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Risk factors for multidrug-resistant Pseudomonas aeruginosa nosocomial infection.

机译：多重耐药性铜绿假单胞菌医院感染的危险因素。

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摘要

A case-control study was conducted in a university hospital to determine the risk factors for nosocomial infection with multidrug-resistant Pseudomonas aeruginosa (MDR-PA) among all hospitalized patients and among those with a nosocomial infection due to P. aeruginosa. Eighty patients infected with MDR-PA, 75 infected with a non-MDR phenotype and 240 random controls were included in the 12-month study. Among all hospitalized patients, age, severity index, having a bedridden condition, transfer from other units, nasogastric feeding, urinary catheterization and exposure to beta-lactams (OR=2.5) or fluoroquinolones (OR=4.1) in the seven days before infection were linked to nosocomial infection due to MDR-PA. Among patients infected by P. aeruginosa, exposure to fluoroquinolones (OR=4.7) or surgery (OR=0.5) were linked to the isolation of MDR-PA. This study showed that, in addition to urinary catheterization, nasogastric feeding is an important risk factor in MDR-PA infection. Indeed, an imbalance in gut flora, modifications to the mucous membranes due to the use of nasogastric feeding and the selection pressures exerted by antibiotics were implicated in the occurrence of this infection.
机译：在一家大学医院进行了一项病例对照研究，以确定所有住院患者和因铜绿假单胞菌导致医院感染的患者中多药耐药的铜绿假单胞菌（MDR-PA）医院感染的危险因素。在为期12个月的研究中，包括80名感染了MDR-PA的患者，75名感染了非MDR表型的患者和240位随机对照。在所有住院患者中，感染前7天的年龄，严重程度指数，卧床不起，从其他单位转移，鼻胃喂养，导尿和暴露于β-内酰胺类（OR = 2.5）或氟喹诺酮类（OR = 4.1）。与MDR-PA引起的医院感染有关。在铜绿假单胞菌感染的患者中，氟喹诺酮类药物（OR = 4.7）或手术（OR = 0.5）的暴露与MDR-PA的分离有关。这项研究表明，除导尿外，鼻胃喂养也是MDR-PA感染的重要危险因素。确实，这种感染的发生与肠道菌群失衡，由于使用鼻胃喂养引起的粘膜改变以及抗生素施加的选择压力有关。

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