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首页> 外文期刊>The Journal of Immunology: Official Journal of the American Association of Immunologists >Identification of a cytoplasmic region of CD20 required for its redistribution to a detergent-insoluble membrane compartment.
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Identification of a cytoplasmic region of CD20 required for its redistribution to a detergent-insoluble membrane compartment.

机译：将CD20重新分配到不溶于清洁剂的膜区室所需的CD20胞质区域的鉴定。

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摘要

CD20 is a B lymphocyte integral membrane protein with signal-transducing properties. Abs directed toward extracellular CD20 epitopes activate nonreceptor tyrosine kinases and modulate cell cycle progression of B lymphocytes. Recently, we demonstrated that binding of CD20 Abs to B cells induces the rapid redistribution of up to 95% of CD20 molecules to low density, detergent-insoluble membrane microdomains and induces the appearance of an approximately 50-kDa tyrosine-phosphorylated protein in the same compartment. Active relocalization of CD20 may thus be critical to the initiation of signaling events by CD20. The CD20 cDNA sequence predicts a nonglycosylated protein with four transmembrane-spanning regions and intracellular amino and carboxyl termini. Here we provide verification of the location of both the intracellular and extracellular regions of the CD20 molecule and identify a membrane-proximal sequence in the cytoplasmic carboxyl tail that is required for CD20 to redistribute to detergent-insoluble membrane microdomains.
机译：CD20是具有信号传导特性的B淋巴细胞整合膜蛋白。针对细胞外CD20表位的Abs激活非受体酪氨酸激酶并调节B淋巴细胞的细胞周期进程。最近，我们证明了CD20 Abs与B细胞的结合可诱导高达95％的CD20分子快速重新分布到低密度，去污剂不溶的膜微区，并诱导大约50 kDa酪氨酸磷酸化的蛋白质出现在同一区域。隔间。因此，CD20的主动重新定位对于CD20启动信号事件可能至关重要。 CD20 cDNA序列预测具有四个跨膜区域以及细胞内氨基和羧基末端的非糖基化蛋白。在这里，我们提供了CD20分子的胞内和胞外区域的位置验证，并确定了CD20重新分配至去污剂不溶性膜微区所需的胞质羧基尾部的膜近端序列。

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