Role of a type IV-like secretion system of Streptococcus suis 2 in the development of streptococcal toxic shock syndrome.

Zhao Y; Liu G; Li S; Wang M; Song J; Wang J; Tang J; Li M; Hu F

首页> 外文期刊>The Journal of Infectious Diseases >Role of a type IV-like secretion system of Streptococcus suis 2 in the development of streptococcal toxic shock syndrome.

【24h】

Role of a type IV-like secretion system of Streptococcus suis 2 in the development of streptococcal toxic shock syndrome.

机译：猪链球菌2型IV型分泌系统在链球菌中毒性休克综合征发展中的作用。

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Streptococcus suis serotype 2 (S. suis 2) has evolved into a highly invasive pathogen that was found to be the cause of 2 large-scale outbreaks of streptococcus toxic shock syndrome (STSS) in China. However, the mechanism of action of this non-group A streptococcal (GAS) S. suis-caused STSS is still unknown. Previously, we identified a unique pathogenicity island (PAI) designated 89K that is specific to the STSS-causing epidemic strains of S. suis 2. In this study, we further report a functional type IV-like secretion system (T4SS-like system) harbored in the 89K PAI that contributes to the development of STSS. Knockout of the 2 key components (VirD4-89K and VirB4-89K) of the T4SS-like system eliminated the lethality of the highly virulent strain and impaired its ability to trigger host immune response in experimental infection of mice. Our findings provide a new insight into the pathogenesis of STSS caused by the highly pathogenic S. suis 2 isolates.

机译：猪链球菌血清型2（猪链球菌2）已演变成一种高度侵入性的病原体，被发现是造成中国两次大规模链球菌中毒性休克综合征（STSS）暴发的原因。但是，这种非A群链球菌（GAS）猪链球菌引起的STSS的作用机制仍然未知。以前，我们确定了一个独特的致病岛（PAI），命名为89K，它专门针对引起猪链球菌2型STSS流行的菌株。在这项研究中，我们进一步报告了功能性IV型分泌系统（T4SS型系统）。包含在有助于STSS发展的89K PAI中。 T4SS样系统的两个关键组件（VirD4-89K和VirB4-89K）的敲除消除了高毒力毒株的致死性，并削弱了其在实验性感染小鼠中触发宿主免疫反应的能力。我们的发现为由高致病性猪链球菌2株引起的STSS发病机理提供了新的见解。

著录项

来源
《The Journal of Infectious Diseases》 |2011年第2期|共8页
作者
Zhao Y; Liu G; Li S; Wang M; Song J; Wang J; Tang J; Li M; Hu F;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类传染病;
关键词

相似文献

外文文献
中文文献
专利

1. Role of a type IV-like secretion system of Streptococcus suis 2 in the development of streptococcal toxic shock syndrome. [J] . Zhao Y, Liu G, Li S, The Journal of Infectious Diseases . 2011,第2期

机译：猪链球菌2型IV型分泌系统在链球菌中毒性休克综合征发展中的作用。
2. Roles of the Putative Type IV-like Secretion System Key Component VirD4 and PrsA in Pathogenesis of Streptococcus suis Type 2 [J] . Fang Weihuan, Gu Yuanxing, Jiang Xiaowu, Frontiers in Cellular and Infection Microbiology . 2016,第2012期

机译：推定的IV型分泌系统关键成分VirD4和PrsA在猪链球菌2型发病中的作用。
3. Mitogenic effect contributes to increased virulence of Streptococcus suis sequence type 7 to cause streptococcal toxic shock-like syndrome. [J] . Zheng H, Ye C, Segura M, Clinical and Experimental Immunology: An Official Journal of the British Society for Immunology . 2008,第3期

机译：致丝分裂作用有助于增加猪链球菌7型序列的毒性，从而引起链球菌中毒性休克样综合征。
4. Involvement of streptococcal superantigens in streptococcal toxic shock syndrome [C] . Lily Yang, Mark Thomas, Andrew Woodhouse, Lancefield International Symposium on Streptococci and Streptococcal Diseases . 2006

机译：链球菌超抗原在链球菌有毒休克综合征中的参与
5. Streptococcus suis capsular type 2 interactions with phagocytic cells. [D] . Segura, Mariela. 2002

机译：猪链球菌2型荚膜与吞噬细胞的相互作用。
6. Roles of the Putative Type IV-like Secretion System Key Component VirD4 and PrsA in Pathogenesis of Streptococcus suis Type 2 [O] . Xiaowu Jiang, Yunkai Yang, Jingjing Zhou, 2016

机译：推测的IV型分泌系统关键成分VirD4和PrsA在猪链球菌2型发病中的作用
7. Roles of the Putative Type IV-like Secretion System Key Component VirD4 and PrsA in Pathogenesis of Streptococcus suis Type 2 [O] . Xiaowu Jiang, Yunkai Yang, Jingjing Zhou, 2016

机译：推定的IV型分泌系统关键成分VirD4和prsa在猪链球菌2型发病机制中的作用

Role of a type IV-like secretion system of Streptococcus suis 2 in the development of streptococcal toxic shock syndrome.

摘要

著录项

相似文献

相关主题

期刊订阅