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首页> 外文期刊>The Journal of Infectious Diseases >The ability of Helicobacter pylori to activate neutrophils is determined by factors other than H. pylori neutrophil-activating protein.
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The ability of Helicobacter pylori to activate neutrophils is determined by factors other than H. pylori neutrophil-activating protein.

机译：幽门螺杆菌激活中性粒细胞的能力由除幽门螺杆菌嗜中性粒细胞激活蛋白以外的因素决定。

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摘要

The ability of Helicobacter pylori to activate neutrophils is associated with peptic ulcer disease (PUD). One of the H. pylori factors previously suggested to stimulate neutrophil activation is the H. pylori neutrophil-activating protein (HpNAP). The primary aims of this study were to investigate the relationships between H. pylori neutrophil activation and reported variations in HpNAP expression and the napA gene sequence. The association between neutrophil activation and vacuolating cytotoxin activity was also investigated. The ability to activate neutrophils was found here to be associated with the development of PUD and was a characteristic more frequently identified in H. pylori isolates with vacuolating cytotoxin activity. However, no relationship was found between neutrophil activation and the expression of HpNAP or differences in the napA sequence. In conclusion, the ability to activate neutrophils contributes to the ulcerative potential of individual H. pylori isolates, but this activity is not mediated by differences in HpNAP.
机译：幽门螺杆菌激活中性粒细胞的能力与消化性溃疡疾病（PUD）有关。以前建议刺激嗜中性粒细胞活化的幽门螺杆菌因子之一是幽门螺杆菌嗜中性粒细胞激活蛋白（HpNAP）。这项研究的主要目的是调查幽门螺杆菌嗜中性粒细胞活化与HpNAP表达和napA基因序列的变异之间的关系。还研究了中性粒细胞活化与空泡细胞毒素活性之间的关系。在这里发现激活嗜中性粒细胞的能力与PUD的发展有关，并且是在具有空泡细胞毒素活性的幽门螺杆菌分离物中更经常发现的特征。然而，在嗜中性粒细胞活化与HpNAP的表达或napA序列的差异之间未发现任何关系。总之，激活嗜中性粒细胞的能力有助于单个幽门螺杆菌分离株的溃疡潜力，但是这种活性不是由HpNAP的差异介导的。

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