Quantification of Human T-lymphotropic virus type I (HTLV-I) provirus load in a rural West African population: no enhancement of human immunodeficiency virus type 2 pathogenesis, but HTLV-I provirus load relates to mortality.

Ariyoshi K; Berry N; Cham F; Jaffar S; Schim van der Loeff M; Jobe O; NGom PT; Larsen O; Andersson S; Aaby P; Whittle H

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Quantification of Human T-lymphotropic virus type I (HTLV-I) provirus load in a rural West African population: no enhancement of human immunodeficiency virus type 2 pathogenesis, but HTLV-I provirus load relates to mortality.

机译：西非农村人口中的人类I型T淋巴细胞病毒（HTLV-1）前病毒负荷的定量：人类2型免疫缺陷病毒的发病机理没有增强，但是HTLV-1 I病毒原负荷与死亡率有关。

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Human T-lymphotropic virus type I (HTLV-I) provirus load was examined in a cohort of a population in Guinea-Bissau among whom human immunodeficiency virus (HIV) type 2 is endemic. Geometric mean of HIV-2 RNA load among HTLV-I-coinfected subjects was significantly lower than that in subjects infected with HIV-2 alone (212 vs. 724 copies/mL; P=.02). Adjusted for age, sex, and HIV status, the risk of death increased with HTLV-I provirus load; mortality hazard ratio was 1.59 for each log10 increase in HTLV-I provirus copies (P=.038). There is no enhancing effect of HTLV-I coinfection on HIV-2 disease, but high HTLV-I provirus loads may contribute to mortality.

机译：在几内亚比绍的一个人群中检查了人类I型T淋巴细胞病毒（HTLV-1）的原病毒载量，其中人类免疫缺陷病毒（HIV）2型是地方性的。 HTLV-1合并感染受试者中HIV-2 RNA载量的几何平均值显着低于单独感染HIV-2的受试者（212 vs. 724拷贝/mL;P=.02）。根据年龄，性别和HIV状况进行调整后，死亡风险会因HTLV-I前病毒载量增加; HTLV-1前病毒拷贝每增加10 log10，死亡率危险比为1.59（P = .038）。 HTLV-1合并感染对HIV-2疾病没有增强作用，但高HTLV-1病毒原载量可能会导致死亡。

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来源
《The Journal of Infectious Diseases》 |2003年第11期|共4页
作者
Ariyoshi K; Berry N; Cham F; Jaffar S; Schim van der Loeff M; Jobe O; NGom PT; Larsen O; Andersson S; Aaby P; Whittle H;
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正文语种 eng
中图分类内科学;
关键词
Human T-lymphotropic virus 1; Proviruses; Aspects of mortality statistics; 原病毒;

机译：Human T-lymphotropic virus 1;Proviruses;Aspects of mortality statistics;原病毒;

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1. Quantification of Human T-lymphotropic virus type I (HTLV-I) provirus load in a rural West African population: no enhancement of human immunodeficiency virus type 2 pathogenesis, but HTLV-I provirus load relates to mortality. [J] . Ariyoshi K, Berry N, Cham F, The Journal of Infectious Diseases . 2003,第11期

机译：西非农村人口中的人类I型T淋巴细胞病毒（HTLV-1）前病毒负荷的定量：人类2型免疫缺陷病毒的发病机理没有增强，但是HTLV-1 I病毒原负荷与死亡率有关。
2. A community-based study of human immunodeficiency virus type 2 provirus load in rural village in West Africa. [J] . Ariyoshi K, Berry N, Wilkins A, The Journal of Infectious Diseases . 1996,第1期

机译：一项基于社区的人类免疫缺陷病毒2型前病毒在西非乡村的研究。
3. Decreased Human T Lymphotropic Virus Type I (HTLV-I) Provirus Load and Alteration in T Cell Phenotype after Interferon-alpha Therapy for HTLV-I-Associated Myelopathy/Tropical Spastic Paraparesis. [J] . Saito M, Kaseda S, Jonosono M, The Journal of Infectious Diseases . 2004,第1期

机译：I型人T淋巴病毒减少（HTLV-I）前病毒载量和HTLV-I相关性脊髓病/热带痉挛性截瘫的干扰素-α治疗后T细胞表型的改变。
4. Simultaneous extraction of human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV) RNA with the M1000 apparatus does not impair the measurement of the viral load of both viruses when tested by using the LCx PCR system [C] . T. Bourlet, S. Thamm, S. Pillet, European Congress of Virology . 2004

机译：通过使用LCX PCR系统测试，同时提取人免疫缺陷病毒类型1（HIV-1）和丙型肝炎病毒（HCV）RNA，不会损害两种病毒的病毒载量的测量
5. Human T-cell lymphotropic virus type I (HTLV-I) activates IL-15Ralpha expression via NF-kappaB and interferon regulatory elements. [D] . Mariner, Jennifer Marie. 2002

机译：I型人T细胞淋巴病毒（HTLV-1）通过NF-κB和干扰素调节元件激活IL-15Ralpha表达。
6. Human T-lymphotropic Virus Type I (HTLV-I) Proviral Load and Clinical Features in Iranian HAM/TSP Patients: Comparison of HTLV-I Proviral Load in HAM/TSP Patients [O] . Rosita Vakili, Faezeh Sabet, Sanaz Aahmadi, 2013

机译：伊朗HAM / TSP患者的I型人T淋巴细胞病毒（HTLV-I）前病毒载量和临床特征：HAM / TSP患者的HTLV-I前病毒载量比较
7. Quantification of Human T-lymphotropic virus type I (HTLV-I) provirus load in a rural West African population: no enhancement of human immunodeficiency virus type 2 pathogenesis, but HTLV-I provirus load relates to mortality [O] . Ariyoshi, Koya, Berry, Neil, Cham, Fatim, 2003

机译：西非农村人口中的人类I型T淋巴细胞病毒（HTLV-I）前病毒载量的定量：人类免疫缺陷病毒2型发病机理没有增强，但是HTLV-1 I病毒前载量与死亡率有关
8. Report on Carcinogens (RoC) Concept: Selected Viruses. Epstein--Barr Virus, Human ImmunodeficiencynVirus Type 1, Human T--Cell Lymphotropic Virus Type 1, Kaposi Sarcoma--Associated Herpes Virus, and nMerkel Cell Polyoma Virus. [R] . 2016

机译：关于致癌物（RoC）概念的报告：选定的病毒。爱泼斯坦 - 巴尔病毒，人类免疫缺陷病毒1型，人类T细胞淋巴细胞病毒1型，卡波西肉瘤 - 相关疱疹病毒和nmerkel细胞多瘤病毒。

Quantification of Human T-lymphotropic virus type I (HTLV-I) provirus load in a rural West African population: no enhancement of human immunodeficiency virus type 2 pathogenesis, but HTLV-I provirus load relates to mortality.

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