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首页> 外文期刊>The Journal of Infectious Diseases >Cefotaxime, desacetyl-cefotaxime, and bactericidal activity in spontaneous bacterial peritonitis.
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Cefotaxime, desacetyl-cefotaxime, and bactericidal activity in spontaneous bacterial peritonitis.

机译：头孢噻肟，去乙酰头孢噻肟和自发性细菌性腹膜炎的杀菌活性。

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摘要

We have prospectively studied 13 episodes of spontaneous bacterial peritonitis (SBP) in 12 patients treated with cefotaxime (CTX) 2 g intravenously every 8 h (mean duration, 5.3 days). Ascitic fluid was inoculated at the bedside. The cultures were done before, during (day 3 after CTX initiation), and 48-72 h (mean, 56 h) after the end of therapy. All SBP episodes were monomicrobial. During treatment, the concentrations of CTX and desacetyl-cefotaxime (d-CTX) in ascitic fluid were high in all 13 SBP episodes, and d-CTX was still present in 6 patients who had residual ascitic bactericidal titer (ABT) activity after the last dose of CTX. ABTs were >/=1:128 during CTX therapy in 12 episodes and were measurable in 7 patients after the last dose. All patients were cured. The present study provides scientific rationale to the clinical studies that suggest treating SBP episodes with lower doses of antibiotics and shorter treatment duration.
机译：我们前瞻性研究了每8小时静脉注射2克头孢噻肟（CTX）治疗的12例患者的自发性细菌性腹膜炎（SBP）的13次发作（平均持续时间5.3天）。在床旁接种腹水。培养在治疗结束之前，期间（CTX启动后第3天）和48-72小时（平均56小时）进行。所有SBP发作均为单微生物。在治疗期间，在所有13次SBP发作中，腹水中CTX和去乙酰头孢噻肟（d-CTX）的浓度均较高，并且在最后一次手术后仍有残留腹水杀菌效价（ABT）的6例患者中仍存在d-CTX。 CTX剂量。在CTX治疗期间12次发作中ABT> / = 1：128，在最后一次给药后7例患者中可测到。所有患者均治愈。本研究为临床研究提供了科学依据，这些临床研究建议用较低剂量的抗生素和较短的治疗时间来治疗SBP发作。

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