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首页> 外文期刊>The Journal of Infectious Diseases >Protection against experimental Staphylococcus aureus arthritis by vaccination with clumping factor A, a novel virulence determinant.
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Protection against experimental Staphylococcus aureus arthritis by vaccination with clumping factor A, a novel virulence determinant.

机译：通过接种丛集因子A（一种新型的毒力决定因素）进行疫苗接种，可预防实验性金黄色葡萄球菌关节炎。

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摘要

The importance of the fibrinogen-binding adhesin clumping factor A (ClfA) in the pathogenesis of Staphylococcus aureus septic arthritis was examined in an animal model. The protective effect of active and passive immunization with ClfA also was investigated in S. aureus infection models. The severity of arthritis was markedly reduced in mice challenged intravenously with a clfA mutant, compared with mice infected with the wild-type strain. Mice immunized with recombinant ClfA and challenged with S. aureus developed less-severe arthritis than did mice immunized with a control antigen. Passive immunization of mice with rat and rabbit anti-ClfA antibodies protected against S. aureus arthritis and sepsis-induced death, indicating that the protection by active immunization is antibody mediated. Taken together, these data strongly suggest that ClfA is a crucial virulence determinant for septic arthritis and an excellent target for the generation of immune therapies directed against S. aureus.
机译：在动物模型中检查了纤维蛋白原结合粘附素聚集因子A（ClfA）在金黄色葡萄球菌败血症性关节炎的发病机理中的重要性。在金黄色葡萄球菌感染模型中也研究了用ClfA主动和被动免疫的保护作用。与用野生型毒株感染的小鼠相比，用clfA突变体静脉内攻击的小鼠的关节炎严重程度明显降低。与用对照抗原免疫的小鼠相比，用重组ClfA免疫并用金黄色葡萄球菌攻击的小鼠发生的严重程度更低。用大鼠和兔抗ClfA抗体对金黄色葡萄球菌关节炎和败血症引起的死亡进行的被动免疫小鼠免疫接种，表明通过主动免疫进行的保护是抗体介导的。综上所述，这些数据强烈表明，ClfA是脓毒性关节炎的关键毒力决定因素，并且是针对金黄色葡萄球菌的免疫疗法产生的极佳靶标。

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