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首页> 外文期刊>The Journal of Infectious Diseases >beta-Herpesvirus (human cytomegalovirus and human herpesvirus 6) reactivation in at-risk lung transplant recipients and in human immunodeficiency virus-infected patients.
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beta-Herpesvirus (human cytomegalovirus and human herpesvirus 6) reactivation in at-risk lung transplant recipients and in human immunodeficiency virus-infected patients.

机译：在有风险的肺移植受者和人类免疫缺陷病毒感染的患者中，β-疱疹病毒（人类巨细胞病毒和人类疱疹病毒6）重新激活。

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摘要

Human herpesvirus (HHV)-6 is a beta-herpesvirus-like human cytomegalovirus (HCMV) with the potential to reactivate in immunocompromised persons. HHV-6 and HCMV were assessed in the peripheral blood leukocytes of 26 lung transplant recipients and of 37 human immunodeficiency virus (HIV)-infected patients receiving highly active antiretroviral therapy, to determine the degree of concordance between HHV-6 and HCMV reactivation in different biologic settings. In the lung transplant recipients (145 samples), HHV-6 was not detected, even though 44 (30%) of 145 samples were from 9 HCMV DNA-positive patients (13 episodes of HCMV pneumonitis). Among the HIV-infected patients (172 samples), HCMV DNA was detected in 29 (17%) of 172 samples from 10 patients (4 episodes of HCMV disease). HHV-6 DNA was detected in 2 HIV-infected patients who did not have HCMV detected at that time. These findings suggest that the pathobiologic control mechanisms for these 2 beta-herpesviruses may be significantly different.
机译：人疱疹病毒（HHV）-6是一种类似于β疱疹病毒的人巨细胞病毒（HCMV），具有在免疫功能低下的人中重新激活的潜力。在26位肺移植受者和37位接受高活性抗逆转录病毒疗法的人类免疫缺陷病毒（HIV）感染患者的外周血白细胞中评估了HHV-6和HCMV，以确定不同情况下HHV-6和HCMV激活之间的一致性程度生物设置。在肺移植接受者（145个样本）中，尽管145个样本中有44个（30％）来自9例HCMV DNA阳性患者（13例HCMV肺炎），但未检测到HHV-6。在受HIV感染的患者（172个样本）中，从10个患者（4例HCMV疾病）的172个样本中，有29个（17％）检测到HCMV DNA。在当时没有检测到HCMV的2名HIV感染患者中检测到HHV-6 DNA。这些发现表明，这两种β-疱疹病毒的病理生物学控制机制可能存在显着差异。

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