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首页> 外文期刊>The Journal of Infectious Diseases >Live Measles Vaccine Expressing the Secreted Form of the West Nile Virus Envelope Glycoprotein Protects against West Nile Virus Encephalitis.
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Live Measles Vaccine Expressing the Secreted Form of the West Nile Virus Envelope Glycoprotein Protects against West Nile Virus Encephalitis.

机译：表达西尼罗河病毒包膜糖蛋白分泌形式的活麻疹疫苗可预防西尼罗河病毒性脑炎。

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摘要

The Schwarz strain of measles virus (MV), a live attenuated RNA virus, is one of the safest and most effective human vaccines available. Immunization with MV vaccine expressing heterologous antigen is an attractive strategy to prevent emerging viral diseases. West Nile virus (WNV), which recently emerged in North America, is an important mosquito-borne flavivirus that causes numerous cases of human encephalitis, thus urging the development of a vaccine. To evaluate the efficacy of recombinant MV for the prevention of WNV encephalitis, we constructed a live attenuated Schwarz MV (MVSchw-sE(WNV)) expressing the secreted form of the envelope glycoprotein from the virulent IS-98-ST1 strain of WNV. Inoculation of MV-susceptible mice with MVSchw-sE(WNV) induced both high levels of specific anti-WNV neutralizing antibodies and protection from a lethal challenge with WNV. Passive administration with antisera to MVSchw-sE(WNV) prevented WNV encephalitis in BALB/c mice challenged with a high dose of WNV. The present study is the first to report that a recombinant live attenuated vector based on an approved and widely used MV vaccine can protect against a heterologous, medically important pathogen.
机译：Schwarz麻疹病毒（MV）减毒活病毒是一种最安全，最有效的人类疫苗。用表达异源抗原的MV疫苗进行免疫是预防新兴病毒性疾病的有吸引力的策略。最近在北美出现的西尼罗河病毒（WNV）是一种重要的蚊媒黄病毒，可引起许多人脑炎，因此促使人们开发疫苗。为了评估重组MV预防WNV脑炎的功效，我们构建了减毒的Schwarz MV（MVSchw-sE（WNV）），可表达来自WNV的强毒IS-98-ST1菌株的包膜糖蛋白的分泌形式。用MVSchw-sE（WNV）接种MV易感小鼠既诱导了高水平的特异性抗WNV中和抗体，又受到了WNV致死性攻击的保护。对MVSchw-sE（WNV）的抗血清被动给药可预防高剂量WNV攻击的BALB / c小鼠的WNV脑炎。本研究是第一个报道基于已批准且广泛使用的MV疫苗的重组减毒活疫苗可以预防异源，医学上重要的病原体的研究。

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