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首页> 外文期刊>The Journal of investigative dermatology. >Narrow Band Ultraviolet B Treatment for Human Vitiligo Is Associated with Proliferation, Migration, and Differentiation of Melanocyte Precursors
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Narrow Band Ultraviolet B Treatment for Human Vitiligo Is Associated with Proliferation, Migration, and Differentiation of Melanocyte Precursors

机译：人类白癜风的窄带紫外线B治疗与黑素细胞前体的增殖，迁移和分化相关。

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In vitiligo, the autoimmune destruction of epidermal melanocytes produces white spots that can be repigmented by melanocyte precursors from the hair follicles, following stimulation with UV light. We examined by immunofluorescence the distribution of melanocyte markers (C-KIT, DCT, PAX3, and TYR) coupled with markers of proliferation (KI-67) and migration (MCAM) in precursors and mature melanocytes from the hair follicle and the epidermis of untreated and narrow band UVB (NBUVB)-treated human vitiligo skin. NBUVB was associated with a significant increase in the number of melanocytes in the infundibulum and with restoration of the normal melanocyte population in the epidermis, which was lacking in the untreated vitiligo. We identified several precursor populations (melanocyte stem cells, melanoblasts, and other immature phenotypes), and progressively differentiating melanocytes, some with putative migratory and/or proliferative abilities. The primary melanocyte germ was present in the untreated and treated hair follicle bulge, whereas a possible secondary melanocyte germ composed of C-KIT+ melanocytes was found in the infundibulum and interfollicular epidermis of UV-treated vitiligo. This is an exceptional model for studying the mobilization of melanocyte stem cells in human skin. Improved understanding of this process is essential for designing better treatments for vitiligo, ultimately based on nnelanocyte stem cell activation and mobilization.
机译：在白癜风中，表皮黑素细胞的自身免疫破坏会产生白斑，在受到紫外线的刺激后，白斑可被毛囊中的黑素细胞前体所抑制。我们通过免疫荧光检查了黑素细胞标记物（C-KIT，DCT，PAX3和TYR）的分布，以及未处理的毛囊和表皮的前体细胞和成熟黑素细胞中的增殖标记物（KI-67）和迁移标记物（MCAM）和窄带UVB（NBUVB）处理的人白癜风皮肤。 NBUVB与漏斗中黑素细胞数量的显着增加以及表皮中正常黑素细胞种群的恢复有关，而未经治疗的白癜风则缺乏这种能力。我们确定了几个前体种群（黑素细胞干细胞，黑素细胞和其他未成熟的表型），并逐步分化黑素细胞，其中一些具有推测的迁移和/或增殖能力。原发黑素细胞胚芽存在于未经处理和处理过的毛囊隆起中，而在紫外线处理过的白癜风的漏斗和小囊间表皮中发现了由C-KIT +黑素细胞组成的继发黑素细胞胚芽。这是研究人类皮肤中黑素细胞干细胞动员的一种特殊模型。更好地了解此过程对于设计更好的白癜风治疗至关重要，最终将基于神经干细胞的活化和动员。

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