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首页> 外文期刊>The Journal of laboratory and clinical medicine >Endotoxin-induced disseminated intravascular coagulation in rabbits: effect of recombinant hirudin on hemostatic parameters, fibrin deposits, and mortality.
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Endotoxin-induced disseminated intravascular coagulation in rabbits: effect of recombinant hirudin on hemostatic parameters, fibrin deposits, and mortality.

机译：内毒素诱导的兔弥散性血管内凝血：重组水rud素对止血参数，纤维蛋白沉积和死亡率的影响。

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摘要

We evaluated the effect of r-hirudin on an experimental model of disseminated intravascular coagulation (DIC) in rabbits, through the continuous infusion of 100 microg/kg/hr of Escherichia coli endotoxin for a period of 6 hours. r-Hirudin (0.05, 0.3, and 0.6 mg/kg/hr) as treatment, or saline solution as placebo, were administered simultaneously with endotoxin. Severe DIC in the endotoxin control group was shown by impairment in hemostatic parameters, kidney fibrin deposition, and a high mortality rate. Medium and high doses of r-hirudin led to an improvement in such DIC-related parameters as platelet numbers and fibrinogen and protein C concentrations. High-dose r-hirudin also reduced consumption of antithrombin III (ATIII). All doses of r-hirudin prevented decreases in tissue plasminogen activator (t-PA) and reduced the increase in plasminogen activator inhibitor-1 (PAI-1) activity observed at 2 hours after endotoxin administration. A significant reduction in kidney fibrin deposition was seen in medium- and high-dose r-hirudin groups. Additionally, the mortality rate in rabbits receiving medium- and high-dose r-hirudin was 10%, and that in rabbits receiving low-dose r-hirudin was 20%, as compared with a mortality rate of 70% in the control group. Protein C activity was significantly lower (p < 0.001) in nonsurviving rabbits. Moreover, there was a strong positive correlation (r = 0.68, p < 0.001) between protein C consumption and kidney fibrin deposition. We conclude that r-hirudin can be a useful drug in the clinical treatment of DIC.
机译：我们通过连续输注100微克/千克/小时的大肠杆菌内毒素6小时来评估r-hirudin对兔弥散性血管内凝血（DIC）实验模型的影响。与内毒素同时给予r-Hirudin（0.05、0.3和0.6 mg / kg / hr）或盐水溶液作为安慰剂。内毒素对照组的严重DIC表现为止血参数受损，肾纤维蛋白沉积和高死亡率。中等剂量和高剂量的r-hirudin导致与DIC相关的参数（如血小板数量以及纤维蛋白原和蛋白C浓度）的改善。大剂量的r-hirudin还减少了抗凝血酶III（ATIII）的消耗。所有剂量的r-hirudin均可以防止内毒素给药后2小时观察到的组织纤溶酶原激活物（t-PA）减少，并降低了纤溶酶原激活物抑制剂1（PAI-1）活性的增加。在中等剂量和大剂量r-hirudin组中，肾纤维蛋白沉积明显减少。另外，接受中等剂量和大剂量r-hirudin的兔子的死亡率为10％，接受低剂量r-hirudin的兔子的死亡率为20％，而对照组的死亡率为70％。在未存活的兔子中，蛋白C的活性显着降低（p <0.001）。此外，蛋白质C的摄入量与肾纤维蛋白沉积之间存在很强的正相关（r = 0.68，p <0.001）。我们得出结论，r-hirudin在DIC的临床治疗中可能是有用的药物。

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