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首页> 外文期刊>The Journal of molecular diagnostics: JMD >Caveolin-1 P132L mutation in human cancers: 1 CAVeat to be voiced.
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Caveolin-1 P132L mutation in human cancers: 1 CAVeat to be voiced.

机译：人类癌症中的Caveolin-1 P132L突变：需要表达1个CAVeat。

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摘要

Caveolae are 50-100 nm flask-shaped imaginations of the plasma membrane that function as membrane organizing centers and play important roles in intracellular trafficking of cellular components (eg, lipid and cholesterol) and signal transduction.1 The CAV1 gene maps to 7q31.1 and encodes the ubiquitously expressed caveolin-1, which is an essential component of caveolae. Caveolin-1 is believed to regulate the activity of a plethora of signaling molecules highly represented in caveolae, such as H-ras, c-src, and src-like kinases; endothelial nitric oxide synthase; G-proteins and membrane-associated receptors coupled to G-proteins; or ty-rosine kinase receptors including epidermal growth factor receptor.1 In normal breast tissue, caveolin-1 is expressed at high levels in adipocytes, endothelial cells, fibroblasts, and myoepithelial cells of the breast.
机译：小窝是质膜的50-100 nm瓶状想象，起着膜组织中心的作用，并在细胞内细胞组分（例如脂质和胆固醇）的运输和信号转导中起重要作用。1CAV1基因映射到7q31.1并编码普遍表达的小窝蛋白1，它是小窝蛋白的基本组成部分。人们认为Caveolin-1调节了许多在小窝中高度代表的信号分子的活性，例如H-ras，c-src和src样激酶。内皮型一氧化氮合酶G蛋白和与G蛋白偶联的膜相关受体; 1或在正常的乳腺组织中，caveolin-1在乳腺的脂肪细胞，内皮细胞，成纤维细胞和肌上皮细胞中高水平表达。

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