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首页> 外文期刊>The Journal of molecular diagnostics: JMD >Detection of Colorectal Cancer Using a Simplified SEPT9 Gene Methylation Assay Is a Reliable Method for Opportunistic Screening
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Detection of Colorectal Cancer Using a Simplified SEPT9 Gene Methylation Assay Is a Reliable Method for Opportunistic Screening

机译：使用简化的SEPT9基因甲基化检测大肠癌是机会性筛查的可靠方法

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摘要

SEPT9 gene methylation was validated as a biomarker for colorectal cancer (CRC) for >10 years and available as the Epi proColon test as an aid in CRC detection for >6 years. It was proven to be an accurate, reliable, fast, and convenient molecular test. In this opportunistic screening study, we validated a further simplified SEPT9 gene methylation assay in 1031 subjects in Chinese hospitals. The sensitivity for CRC detection was 76.6% at a specificity of 95.9%, and the results showed a satisfactory detection rate for each CRC stage, including early stages. The new SEPT9 assay, with enhanced technical simplicity, convenience, and lower cost, did not differ in performance compared with Epi proColon 2.0, the commercialized SEPT9 assay. The CRC detection sensitivity was further enhanced when the assay was combined with carcinoembryonic antigen (sensitivity, 86.4%) or fecal immunochemical test (sensitivity, 94.4%), suggesting that the combined tests may be an effective option for future opportunistic screening. In brief, our study has validated a new SEPT9 assay and combined testing as an aid in cancer detection, providing a new approach for opportunistic CRC screening.
机译：SEPT9基因甲基化已被证明可作为大肠癌（CRC）的生物标志物使用超过10年，并且可以作为Epi ProColon测试来用于CRC检测> 6年。它被证明是一种准确，可靠，快速，方便的分​​子测试。在这项机会筛选研究中，我们在中国医院的1031名受试者中验证了进一步简化的SEPT9基因甲基化测定。 CRC检测的灵敏度为76.6％，特异性为95.9％，结果显示，每个CRC阶段（包括早期阶段）的检测率均令人满意。与商业化SEPT9检测技术Epi ProColon 2.0相比，新的SEPT9检测技术具有增强的技术简便性，便利性和较低的成本，在性能上没有差异。当该测定与癌胚抗原（敏感性，86.4％）或粪便免疫化学试验（敏感性，94.4％）结合使用时，CRC检测的敏感性进一步提高，提示联合检测可能是未来机会性筛查的有效选择。简而言之，我们的研究已经验证了一种新的SEPT9测定法和联合检测法，可以帮助癌症检测，为机会性CRC筛查提供了一种新方法。

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