Use of low-dose gabapentin for aggressive behavior in vascular and mixed vascular/alzheimer dementia.

Colm Cooney; Sinead Murphy; Hiberet Tessema; Aideen Freyne

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Use of low-dose gabapentin for aggressive behavior in vascular and mixed vascular/alzheimer dementia.

机译：低剂量加巴喷丁在血管性和混合性血管/阿尔茨海默氏痴呆症中的侵略性行为的用途。

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Recent reports highlighting serious adverse effects of antipsychotic medication in behavioral and psychological symptoms of dementia (BPSD) has led to calls for research on alternative agents. The authors describe the use of low-dose gabapentin to treat seven patients with a diagnosis of ICD-10 vascular or Mixed Vascular/Alzheimer Dementia with serious aggressive behavior. All seven patients had impressive and clinically significant responses to treatment. Treatment was tolerated in each case without adverse reactions. Our findings suggest that gabapentin should be considered for treating aggressive behavior in patients with vascular or mixed dementia and that it is well tolerated in this context.

机译：最近的报告强调了抗精神病药物对痴呆的行为和心理症状（BPSD）的严重不利影响，导致人们呼吁研究替代药物。作者介绍了使用小剂量加巴喷丁治疗7例诊断为ICD-10血管性或混合性血管/阿尔茨海默氏痴呆且具有严重攻击行为的患者。所有七名患者对治疗都有令人印象深刻且临床上有意义的反应。每种情况下均耐受治疗，无不良反应。我们的发现表明，应考虑使用加巴喷丁治疗血管性或混合性痴呆患者的攻击行为，在这种情况下耐受性良好。

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《The Journal of neuropsychiatry and clinical neurosciences》 |2013年第2期|共6页
作者
Colm Cooney; Sinead Murphy; Hiberet Tessema; Aideen Freyne;
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中图分类神经病学与精神病学;
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1. Use of low-dose gabapentin for aggressive behavior in vascular and mixed vascular/alzheimer dementia. [J] . Colm Cooney, Sinead Murphy, Hiberet Tessema, The Journal of neuropsychiatry and clinical neurosciences . 2013,第2期

机译：低剂量加巴喷丁在血管性和混合性血管/阿尔茨海默氏痴呆症中的侵略性行为的用途。
2. Linkage to 20p13 including the ANGPT4 gene in families with mixed Alzheimer's disease and vascular dementia. [J] . Sillen A, Brohede J, Lilius L, Journal of human genetics . 2010,第10期

机译：在患有混合性阿尔茨海默氏病和血管性痴呆的家庭中与包括ANGPT4基因在内的20p13连锁。
3. Linkage to 20p13 including the ANGPT4 gene in families with mixed Alzheimer's disease and vascular dementia. [J] . Sillen A, Brohede J, Lilius L, Journal of human genetics . 2010,第10期

机译：在患有混合性阿尔茨海默氏病和血管性痴呆的家庭中与包括ANGPT4基因在内的20p13连锁。
4. Large scale serial two-photon microscopy to investigate local vascular changes in whole rodent brain models of Alzheimer's disease [C] . P. Delafontaine-Martel, J. Lefebvre, R. Damseh, Conference on multiphoton microscopy in the biomedical sciences . 2018

机译：大规模连续两光子显微镜研究阿尔茨海默氏病整个啮齿动物脑模型中的局部血管变化
5. Differential scoring patterns on the clock drawing test: A comparison of vascular dementia and Alzheimer's dementia. [D] . Everitt, Alaina. 2006

机译：钟表测试中的差异评分模式：血管性痴呆和阿尔茨海默氏痴呆的比较。
6. Education and prevalence of Alzheimers disease and vascular dementia. Premorbid ability influences measures used to identify dementia. [O] . R. OCarroll, K. Ebmeier 1995

机译：阿尔茨海默氏病和血管性痴呆的教育和患病率。病前能力影响用于识别痴呆症的措施。
7. Motor cortex excitability in Alzheimer's disease and in subcortical ischemic vascular dementia. [O] . Alagona, Giovanna, Ferri, Raffaele, Pennisi, Giovanni, 2004

机译：运动性皮层兴奋性在阿尔茨海默氏病和皮层下缺血性血管性痴呆中。

Use of low-dose gabapentin for aggressive behavior in vascular and mixed vascular/alzheimer dementia.

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