Rostral anterior cingulate activity in major depressive disorder: state or trait marker of responsiveness to medication?

Aimee M Hunter; Alexander S Korb; Ian A Cook; Andrew F Leuchter

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Rostral anterior cingulate activity in major depressive disorder: state or trait marker of responsiveness to medication?

机译：重度抑郁症患者的延髓前扣带回活动：对药物反应的状态或特征标记？

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High rostral anterior cingulate cortex (rACC) activity has been shown to predict antidepressant treatment response; however, it is unclear whether this is a fixed versus variable marker of responsiveness. The authors measured rACC theta current density in 22 subjects 5 weeks before and again immediately before 5 weeks of blinded treatment with sertraline. Mixed-effects regression analysis found that the relationship between response and rACC activity depended significantly on the timing of the rACC assessment; rACC activity measured immediately before treatment was a significantly better predictor of response. rACC activity may constitute a variable "state" indicator of responsiveness to antidepressants.

机译：鼻前扣带回皮层（rACC）的高活性已被证明可以预测抗抑郁药的治疗反应。然而，目前尚不清楚这是否是固定的或可变的响应标记。作者在舍曲林盲法治疗5周之前和5周之前和之后的22周受试者中测量了rACC theta电流密度。混合效应回归分析发现，反应与rACC活性之间的关系在很大程度上取决于rACC评估的时间。治疗前即刻测量的rACC活性可以更好地预测反应。 rACC活性可能构成抗抑郁药反应性的可变“状态”指标。

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《The Journal of neuropsychiatry and clinical neurosciences》 |2013年第2期|共8页
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Aimee M Hunter; Alexander S Korb; Ian A Cook; Andrew F Leuchter;
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中图分类神经病学与精神病学;
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1. Rostral anterior cingulate activity in major depressive disorder: state or trait marker of responsiveness to medication? [J] . Aimee M Hunter, Alexander S Korb, Ian A Cook, The Journal of neuropsychiatry and clinical neurosciences . 2013,第2期

机译：重度抑郁症患者的延髓前扣带回活动：对药物反应的状态或特征标记？
2. Plasma Neuronal and Glial Markers and Anterior Cingulate Metabolite Levels in Major Depressive Disorder: A Pilot Study [J] . Gules Emrah, Iosifescu Dan Vlad, Tural Umit Neuropsychobiology . 2020,第3期

机译：血浆神经元和胶质标志物和前型抑制代谢物水平主要抑郁症：试验研究
3. Rostral anterior cingulate cortex activity mediates the relationship between the depressive symptoms and the medial prefrontal cortex activity. [J] . Shigetoyamawaki Journal of affective disorders . 2010,第1a2期

机译：延髓前扣带回皮层活动介导抑郁症状和内侧前额叶皮层活动之间的关系。
4. Negative BOLD response and serotonin concentration within rostral subgenual portion of the anterior cingulate cortex for long-allele carriers during perceptual processing of emotional tasks [C] . Shamil M. Hadi, Mohamad R. Siadat Conference on biomedical applications in molecular, structural, and functional imaging . 2012

机译：长等位基因携带者在情感任务的知觉处理过程中前扣带回皮下喙状亚部分内的负大胆反应和血清素浓度
5. Investigating Rostral Anterior Cingulate Cortex in Major Depression: An EEG Source Localization Approach. [D] . Korb, Alexander Samuel. 2010

机译：调查在严重抑郁症的延髓前扣带回皮层：一种脑电图源定位方法。
6. Rostral anterior cingulate cortex activity and early symptom improvement during treatment for major depressive disorder [O] . Alexander S. Korb, Aimee M. Hunter, Ian A. Cook, -1

机译：rostral前粒子刺伤皮质活性和治疗主要抑郁症的早期症状改善
7. Rostral anterior cingulate cortex activity and early symptom improvement during treatment for major depressive disorder [O] . Alexander S. Korb, Aimee M. Hunter, Ian A. Cook, 2011

机译：rostral前粒子刺伤皮质活性和治疗主要抑郁症的早期症状改善

Rostral anterior cingulate activity in major depressive disorder: state or trait marker of responsiveness to medication?

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