首页> 外文期刊>The Journal of Neuroscience: The Official Journal of the Society for Neuroscience >Neuronal systems underlying behaviors related to nicotine addiction: neural circuits and molecular genetics.
【24h】

Neuronal systems underlying behaviors related to nicotine addiction: neural circuits and molecular genetics.

机译:与尼古丁成瘾有关的行为的神经元系统:神经回路和分子遗传学。

获取原文
获取原文并翻译 | 示例
           

摘要

Nicotine addiction is a complex behavioral phenomenon comprising effects on several neural systems. Recent studies have expanded initial observations that the actions of nicotine on dopaminergic systems increase dopaminergic activity and release, leading to nicotine-induced reinforcement. Indeed, the actions of nicotine on many systems, including brainstem cholinergic, GABAergic, noradrenergic, and serotonergic nuclei, may help to mediate nicotine effects related to addiction. Furthermore, studies of mice lacking nicotinic acetylcholine receptor subunits or expressing supersensitive forms of these subunits have begun to tie together the molecular, neurochemical, and behavioral effects of nicotine. The use of multiple techniques by many laboratories provides optimism that the field is advancing toward elucidating the basic mechanisms of nicotine dependence.
机译:尼古丁成瘾是一种复杂的行为现象,包括对多个神经系统的影响。最近的研究扩大了最初的观察,即尼古丁对多巴胺能系统的作用增加了多巴胺能的活性和释放,从而导致尼古丁引起的增强作用。确实,尼古丁在许多系统上的作用,包括脑干胆碱能,GABA能,去甲肾上腺素能和血清素能的核,可能有助于介导与成瘾有关的尼古丁效应。此外,对缺乏烟碱型乙酰胆碱受体亚基或表达这些亚基超敏感形式的小鼠的研究已开始将尼古丁的分子,神经化学和行为作用联系在一起。许多实验室对多种技术的使用使人们乐观地认为该领域正在朝着阐明尼古丁依赖性的基本机制前进。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号