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首页> 外文期刊>The Journal of Neuroscience: The Official Journal of the Society for Neuroscience >Modulation of early olfactory processing by an octopaminergic reinforcement pathway in the honeybee.
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Modulation of early olfactory processing by an octopaminergic reinforcement pathway in the honeybee.

机译：蜜蜂中的章鱼胺强化途径对早期嗅觉处理的调节。

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摘要

Processing of olfactory information in the antennal lobes of insects and olfactory bulbs of vertebrates is modulated by centrifugal inputs that represent reinforcing events. Octopamine release by one such pathway in the honeybee antennal lobe modulates olfactory processing in relation to nectar (sucrose) reinforcement. To test more specifically what role octopamine plays in the antennal lobe, we used two treatments to disrupt an octopamine receptor from Apis mellifera brain (AmOAR) function: (1) an OAR antagonist, mianserin, was used to block receptor function, and (2) AmOAR double-stranded RNA was used to silence receptor expression. Both treatments inhibited olfactory acquisition and recall, but they did not disrupt odor discrimination. These results suggest that octopamine mediates consolidation of a component of olfactory memory at this early processing stage in the antennal lobe. Furthermore, after consolidation, octopamine release becomes essential for recall, which suggests that the modulatory circuits become incorporated as essential components of neural representations that activate odor memory.
机译：昆虫触角叶和脊椎动物嗅球中嗅觉信息的处理是通过代表增强事件的离心输入进行调节的。蜜蜂触角叶中一个这样的途径释放的章鱼胺可调节与花蜜（蔗糖）增强有关的嗅觉处理。为了更具体地测试章鱼胺在触角叶中的作用，我们使用了两种治疗方法来破坏蜜蜂Apis mellifera脑（AmOAR）功能中的章鱼胺受体：（1）使用OAR拮抗剂mianserin来阻断受体功能，以及（2 ）AmOAR双链RNA用于沉默受体表达。两种处理均抑制了嗅觉的获取和记忆，但它们并未破坏气味的辨别力。这些结果表明，章鱼胺在触角叶的这个早期处理阶段介导了嗅觉记忆成分的巩固。此外，整合后，释放回忆录中的章鱼胺变得至关重要，这表明调节电路已被整合为激活气味记忆的神经表征的重要组成部分。

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