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首页> 外文期刊>The Journal of Neuroscience: The Official Journal of the Society for Neuroscience >Recovery of amiloride-sensitive neural coding during regeneration of the gustatory nerve: behavioral-neural correlation of salt taste discrimination.
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Recovery of amiloride-sensitive neural coding during regeneration of the gustatory nerve: behavioral-neural correlation of salt taste discrimination.

机译：味觉神经再生过程中对阿米洛利敏感的神经编码的恢复：盐味辨别的行为神经相关性。

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摘要

The chorda tympani (CT) nerve innervating the anterior tongue contains two types of NaCl-responsive fibers: one, the N-type, receives input from receptor cells, the NaCl responses of which are strongly inhibited by amiloride, whereas the other, the E-type, receives input from cells poorly sensitive or insensitive to amiloride. To investigate the formation of this differentially responsive neural system, we crushed the mouse CT nerve and examined the subsequent recovery of NaCl responses and amiloride sensitivity of the regenerated nerve and behavioral discrimination between NaCl and KCl. At 2 weeks after the nerve crush, no significant response of the nerve to chemical stimuli was observed. At 3 weeks, responses to salts gradually reappeared. In this period, almost all single fibers responding to NaCl were insensitive to amiloride (E-type). At 4 weeks, some of the single fibers showed amiloride sensitivity (N-type) and behavioral discrimination between NaCl and KCl reappeared. After >or=5 weeks, the number of N-type fibers had reached the control level and became approximately equal to that of E-type fibers. During the course of recovery, N-type and E-type fibers were clearly distinguishable on the basis of their amiloride sensitivities, their KCl/NaCl response ratios, and their concentration-response relationships to NaCl. These results suggest that two salt-responsive systems are independently reformed after the nerve crush. The selective synapse reformation may account for recovery of behavioral discrimination between NaCl and KCl after taste nerve crush and regeneration. It may also explain stable sensory coding for taste quality during the continuous turnover of receptor cells in the healthy animal.
机译：支配前舌的鼓膜（CT）神经包含两种类型的NaCl响应纤维：一种是N型，接收来自受体细胞的输入，其氯化钠响应受到阿米洛利的强烈抑制，而另一种是E -型，从对阿米洛利敏感性差或不敏感的细胞接受输入。为了研究这种差异反应神经系统的形成，我们压下了老鼠的CT神经，并检查了随后的NaCl反应恢复和再生神经的阿米洛利敏感性以及NaCl和KCl之间的行为区分。神经挤压后2周，未观察到神经对化学刺激的明显反应。在第3周，对盐的反应逐渐出现。在此期间，几乎所有对NaCl敏感的单纤维均对阿米洛利（E型）不敏感。在第4周时，一些单纤维显示出阿米洛利敏感性（N型），并且再次出现了NaCl和KCl之间的行为区分。在≥5周后，N型纤维的数量已达到对照水平，并变得大致等于E型纤维。在恢复过程中，基于阿米洛利敏感性，KCl / NaCl反应比以及它们与NaCl的浓度-反应关系，可以清楚地区分N型和E型纤维。这些结果表明，神经挤压后，两个盐反应系统被独立地改造。选择性突触再形成可能解释了味觉神经压迫和再生后NaCl和KCl之间行为辨别力的恢复。这也可以解释在健康动物中受体细胞连续转换期间对味觉质量的稳定感觉编码。

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