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首页> 外文期刊>The Journal of Neuroscience: The Official Journal of the Society for Neuroscience >Functional reorganization of the motor cortex in adult rats after cortical lesion and treatment with monoclonal antibody IN-1.
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Functional reorganization of the motor cortex in adult rats after cortical lesion and treatment with monoclonal antibody IN-1.

机译：成年大鼠皮质病变和单克隆抗体IN-1治疗后运动皮质的功能重组。

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摘要

We previously reported anatomical plasticity in the adult motor cortex after a unilateral sensorimotor cortex (SMC) lesion and treatment with monoclonal antibody (mAb) IN-1, which permits neurite outgrowth from the intact, opposite cortex into deafferented subcortical targets. This study was designed to investigate whether treatment with the mAb IN-1 after SMC lesion in the adult leads to functional reorganization of the intact, opposite motor cortex. Adult rats underwent unilateral SMC aspiration lesion and treatment with either mAb IN-1 or control antibody, or no treatment. After a 6 week survival period, the intact, opposite forelimb motor cortex was explored using intracortical microstimulation to evoke forelimb movements. A dramatic increase in ipsilateral movements of the lesion-impaired forelimb was found in animals treated with mAb IN-1 compared with control animals. These results resembled our previous findings of cortical reorganization in the spared hemisphere after neonatal cortical lesion and without any additional treatment. These results show that, after adult cortical lesion, treatment with mAb IN-1 induces a functional reorganization of the intact, opposite motor cortex.
机译：我们之前曾报道过单侧感觉运动皮层（SMC）病变并用单克隆抗体（mAb）IN-1处理后，成人运动皮层的解剖可塑性，这允许神经突从完整的对立皮层长出，进入脱皮的皮层下靶标。这项研究旨在调查在成年SMC损伤后使用mAb IN-1进行的治疗是否会导致完整，相对运动皮层的功能重组。成年大鼠经历单侧SMC抽吸病灶，并用mAb IN-1或对照抗体进行治疗，或不进行任何治疗。在6周的生存期之后，使用皮层内微刺激激发前肢运动，探索完整的，相对的前肢运动皮层。与对照动物相比，在用mAb IN-1治疗的动物中发现病变受损的前肢的同侧运动显着增加。这些结果与我们先前对新生儿皮层病变后无需任何其他治疗的半球皮层重组的发现相似。这些结果表明，在成年皮质病变后，用mAb IN-1进行治疗可诱导完整的相对运动皮层的功能重组。

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