Removal of AMPA receptors (AMPARs) from synapses is preceded by transient endocytosis of extrasynaptic AMPARs.

Ashby MC; De La Rue SA; Ralph GS; Uney J; Collingridge GL; Henley JM

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Removal of AMPA receptors (AMPARs) from synapses is preceded by transient endocytosis of extrasynaptic AMPARs.

机译：突触外AMPAR的瞬时胞吞作用是先从突触中去除AMPA受体（AMPAR）。

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AMPA receptors (AMPARs) are dynamically regulated at synapses, but the time course and location of their exocytosis and endocytosis are not known. Therefore, we have used ecliptic pHluorin-tagged glutamate receptor 2 to visualize changes in AMPAR surface expression in real time. We show that synaptic and extrasynaptic AMPARs respond very differently to NMDA receptor activation; there is a rapid internalization of extrasynaptic AMPARs that precedes the delayed removal of synaptic AMPARs.

机译：AMPA受体（AMPAR）在突触中受到动态调节，但其胞吐作用和胞吞作用的时间进程和位置尚不清楚。因此，我们已使用黄道pHluorin标记的谷氨酸受体2实时可视化AMPAR表面表达的变化。我们显示突触和突触外AMPARs对NMDA受体激活的反应非常不同。在延迟移除突触AMPAR之前，突触外AMPAR迅速内部化。

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来源
《The Journal of Neuroscience: The Official Journal of the Society for Neuroscience》 |2004年第22期|共5页
作者
Ashby MC; De La Rue SA; Ralph GS; Uney J; Collingridge GL; Henley JM;
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正文语种 eng
中图分类神经病学与精神病学;
关键词
Endocytosis; Neurons; Receptors; AMPA; Synapses; 细胞内摄作用; 神经元; 受体; AMPA; 突触;

机译：Endocytosis;Neurons;Receptors;AMPA;Synapses;细胞内摄作用;神经元;受体;AMPA;突触;

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1. Removal of AMPA receptors (AMPARs) from synapses is preceded by transient endocytosis of extrasynaptic AMPARs. [J] . Ashby MC, De La Rue SA, Ralph GS, The Journal of Neuroscience: The Official Journal of the Society for Neuroscience . 2004,第22期

机译：突触外AMPAR的瞬时胞吞作用是先从突触中去除AMPA受体（AMPAR）。
2. Prolonged adenosine A1 receptor activation in hypoxia and pial vessel disruption focal cortical ischemia facilitates clathrin-mediated AMPA receptor endocytosis and long- lasting synaptic inhibition in rat hippocampal CA3-CA1 Synapses: Differential regulation of GluA2 and GluA1 Subunits by p38 MAPK and JNK [J] . ChenZ., XiongC., PancyrC., The Journal of Neuroscience: The Official Journal of the Society for Neuroscience . 2014,第29期

机译：缺氧和部分脉管血管局灶性局部缺血中腺苷A1受体的延长活化促进网格蛋白介导的AMPA受体内吞和对大鼠海马CA3-CA1突触的持久突触抑制：p38 MAPK和JNK对GluA2和GluA1亚基的差异调节
3. Synaptotagmin-3 drives AMPA receptor endocytosis, depression of synapse strength, and forgetting [J] . Awasthi Ankit, Ramachandran Binu, Ahmed Saheeb, Science . 2019,第6422期

机译：Synaptotagmin-3驱动AMPA受体的内吞作用，突触强度降低和遗忘
4. Ethanol Promotes Clathrin Adaptor Mediated Endocytosis of Extrasynaptic Alpha4beta3delta GABA(A) Receptors [D] . Gonzalez, Claudia 2011

机译：乙醇促进网格蛋白适配器介导的突触外Alpha4beta3delta GABA（A）受体的内吞作用。
5. Removal of AMPA Receptors (AMPARs) from Synapses Is Preceded by Transient Endocytosis of Extrasynaptic AMPARs [O] . Michael C. Ashby, Sarah A. De La Rue, G. Scott Ralph, 2004

机译：从突触外AMPAR的瞬时内吞作用开始从突触中除去AMPA受体（AMPAR）。
6. Removal of AMPA receptors (AMPARs) from synapses is preceded by transient endocytosis of extrasynaptic AMPARs [O] . Ashby, MC, De La Rue, Sarah A, Ralph, GS, 2004

机译：从突触中去除AMPA受体（AMPAR）之前，突触外AMPAR的瞬时内吞作用

Removal of AMPA receptors (AMPARs) from synapses is preceded by transient endocytosis of extrasynaptic AMPARs.

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