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首页> 外文期刊>The Journal of Neuroscience: The Official Journal of the Society for Neuroscience >Behavioral effects mediated by the modulatory glycine site of the NMDA receptor in the anterodorsal striatum and nucleus accumbens.
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Behavioral effects mediated by the modulatory glycine site of the NMDA receptor in the anterodorsal striatum and nucleus accumbens.

机译：NMDA受体在前额纹状体和伏隔核中的甘氨酸调节位点介导的行为效应。

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The striatum and the nucleus accumbens are the main input structures of the basal ganglia (BG). They contribute differently to motor behavior controlled by the BG in rats, e.g., stereo-typed behavior, catalepsy, and locomotion. Whereas the striatum is predominantly involved in the control of sniffing behavior and catalepsy, the nucleus accumbens contributes to control of locomotion. To test whether the allosteric glycine site of the NMDA receptor complex modulates these behavioral variables, we injected the glycine-site antagonist 7-chlorokynurenate and the glycine-site agonist D-serine into the anterodorsal striatum and the nucleus accumbens and studied their influence on stereotypical snout contacts and locomotion. Additionally, the effects of intrastriatal injections of 7-chlorokynurenate on haloperidol- and SCH 23390-induced catalepsy were investigated. 7-Chlorokynurenate enhanced stereotypical snout contacts in the anterodorsal striatum and in the nucleus accumbens but did not change spontaneous locomotion in either of these structures. Haloperidol- but not SCH 23390-induced catalepsy was attenuated by intrastriatally administered 7-chlorokynurenate. The glycine-site agonist D-serine had no effect on stereotypical snout contacts and locomotion. The results suggest that motor behavior mediated by the striatopallidal output pathway is modulated by the glycine site, whereas motor behavior mediated by the accumbopallidal and striatonigral output pathway is not.
机译：纹状体和伏隔核是基底神经节（BG）的主要输入结构。它们对大鼠BG控制的运动行为的贡献不同，例如刻板行为，僵直和运动。纹状体主要参与嗅探行为和僵直症的控制，伏隔核有助于运动的控制。为了测试NMDA受体复合物的变构甘氨酸位点是否能调节这些行为变量，我们将甘氨酸位点拮抗剂7-氯基尿酸酯和甘氨酸位点激动剂D-丝氨酸注射到前体纹状体和伏隔核中，并研究它们对定型的影响鼻子接触和运动。另外，研究了纹状体内注射7-氯基脲酸酯对氟哌啶醇和SCH 23390引起的僵直症的影响。 7-氯草酸尿酸盐增强了前角纹状体和伏隔核中的定型口鼻部接触，但在这些结构中的任何一个中均未改变自发运动。纹状体内注射7-氯尿嘧啶酮可减轻氟哌啶醇而不是SCH 23390诱导的僵直。甘氨酸位点激动剂D-丝氨酸对定型口鼻部接触和运动没有影响。结果表明，由糖体位置调节的由纹状体的输出途径介导的运动行为，而由糖醛酸位点和纹状体的输出途径介导的运动行为则不受调节。

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