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首页> 外文期刊>The Journal of Neuroscience: The Official Journal of the Society for Neuroscience >Effects of unilateral prefrontal lesions on familiarity, recollection, and source memory.
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Effects of unilateral prefrontal lesions on familiarity, recollection, and source memory.

机译：单侧前额叶病变对熟悉度，记忆力和源记忆的影响。

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摘要

Recognition memory can be supported by both the assessment of the familiarity of an item and by recollection of the context in which an item was encountered. Some have hypothesized that the prefrontal cortex (PFC) disproportionately contributes to recollection, whereas an alternative view is that the PFC contributes to both recollection and familiarity. Here, we examined the effects of prefrontal lesions on recollection and familiarity. Patients with unilateral PFC lesions and age-, gender-, and education-matched controls encoded pictures of meaningful objects that were presented briefly to the left or right visual field and subsequently performed recognition tests for centrally presented objects. Laterality effects within the PFC were also assessed in relation to recollection and familiarity processes. Patients with prefrontal lesions showed impaired familiarity-based recognition, and this deficit was specific for objects encoded by the lesioned hemisphere. In addition, recollection of the context in which each item was encountered was impaired independent of the visual field of presentation in patients with left prefrontal lesions. Recollection measured by subjective reports ("remember") was not impaired in either left or right frontal patients. These findings suggest that the PFC plays a critical role in recognition memory based on familiarity as well as recollection. Furthermore, these results suggest that left PFC regions are critical for source recollection.
机译：可以通过对项目的熟悉程度的评估和对遇到项目的上下文的回忆来支持识别记忆。一些人假设前额叶皮层（PFC）有助于回忆，而另一种观点认为PFC有助于回忆和熟悉。在这里，我们检查了额叶前病变对记忆和熟悉度的影响。具有单侧PFC病变，年龄，性别和教育程度相匹配的对照的患者对有意义的物体的图片进行编码，然后将这些物体简短地显示在左侧或右侧视野中，然后对位于中央的物体进行识别测试。还对PFC内部的横向影响进行了回忆和熟悉过程的评估。额前病变患者表现出基于熟悉度的识别受损，并且这种缺陷是病变半球编码的物体所特有的。此外，与左前额叶病变患者的表现视野无关，对遇到每个项目的背景的记忆也受到损害。左，右额叶患者的主观报告（“记忆”）测量的回忆均未受损。这些发现表明，PFC在基于熟悉度和记忆力的识别记忆中起着至关重要的作用。此外，这些结果表明，左侧的PFC区域对于源回收至关重要。

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