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首页> 外文期刊>The Journal of Neuroscience: The Official Journal of the Society for Neuroscience >Glutamate receptors in perirhinal cortex mediate encoding, retrieval, and consolidation of object recognition memory.
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Glutamate receptors in perirhinal cortex mediate encoding, retrieval, and consolidation of object recognition memory.

机译：周围神经皮层中的谷氨酸受体介导对象识别记忆的编码，检索和巩固。

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摘要

Object recognition is consistently impaired in human amnesia and animal models thereof. Results from subjects with permanent brain damage have revealed the importance of the perirhinal cortex to object recognition memory. Here, we report evidence from rats for interdependent but distinct stages in object recognition memory (encoding, retrieval, and consolidation), which require glutamate receptor activity within perirhinal cortex. Transient blockade of AMPA receptor-mediated synaptic transmission within perirhinal cortex disrupted encoding for short- and long-term memory as well as retrieval and consolidation. In contrast, transient NMDA receptor blockade during encoding affected only long-term object recognition memory; NMDA receptor activity was also necessary for consolidation but not retrieval. These results further demonstrate the importance of perirhinal cortex for object recognition memory and suggest that, as in the hippocampus, AMPA and NMDA receptors mediate synaptic transmission and activity-dependent synaptic plasticity, respectively, in several stages of memory processing.
机译：在人类健忘症及其动物模型中，物体识别始终受到损害。患有永久性脑损伤的受试者的结果表明，周围神经皮层对物体识别记忆的重要性。在这里，我们从大鼠中报告了对象识别记忆（编码，检索和巩固）中相互依存但又不同的阶段的证据，这些阶段需要谷氨酸受体在周围皮层内活动。围堰皮质内AMPA受体介导的突触传递的暂时性阻断破坏了短期和长期记忆以及检索和巩固的编码。相反，在编码过程中短暂的NMDA受体阻滞仅影响长期目标识别记忆;反之， NMDA受体活性对于巩固而不是恢复也是必需的。这些结果进一步证明了周围神经皮层对于对象识别记忆的重要性，并且表明，如在海马中一样，AMPA和NMDA受体分别在记忆处理的几个阶段中介导突触传递和活性依赖性突触可塑性。

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