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首页> 外文期刊>The Journal of Neuroscience: The Official Journal of the Society for Neuroscience >Different sensory systems share projection neurons but elicit distinct motor patterns.
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Different sensory systems share projection neurons but elicit distinct motor patterns.

机译：不同的感觉系统共享投射神经元，但引起不同的运动模式。

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Considerable research has focused on issues pertaining to sensorimotor integration, but in most systems precise information remains unavailable regarding the specific pathways by which different sensory systems regulate any single central pattern-generating circuit. We address this issue by determining how two muscle stretch-sensitive neurons, the gastropyloric receptor neurons (GPRs), influence identified projection neurons that regulate the gastric mill circuit in the stomatogastric nervous system of the crab and then comparing these actions with those of the ventral cardiac neuron (VCN) mechanosensory system. Here, we show that the GPR neurons activate the gastric mill rhythm in the stomatogastric ganglion (STG) via their excitation of two identified projection neurons, modulatory commissural neuron 1 (MCN1) and commissural projection neuron 2 (CPN2), in the commissural ganglion. Support for this conclusion comes from the ability of the modulatory proctolin neuron (MPN), a projection neuron that suppresses the gastric mill rhythm via its inhibitory actions on MCN1 and CPN2, to inhibit the GPR-elicited gastric mill rhythm. Selective elimination of MCN1 and CPN2 access to the STG also prevents GPR activation of this rhythm. The VCN neurons also elicit the gastric mill rhythm by coactivating MCN1 and CPN2, but the GPR-elicited gastric mill rhythm is distinct. These distinct rhythms are likely to result partly from different MCN1 activity levels under these two conditions and partly from the presence of additional GPR actions in the STG. These results support the hypothesis that different sensory systems differentially regulate neuronal circuit activity despite their convergent actions on a single subpopulation of projection neurons.
机译：大量的研究集中在与感觉运动整合有关的问题上，但是在大多数系统中，关于不同的感觉系统调节任何单个中央模式产生电路的具体途径，仍然没有精确的信息。我们通过确定两个肌肉舒张敏感神经元（胃食道受体神经元（GPRs））如何影响已识别的投射神经元（它们调节蟹的气孔胃神经系统中的胃碾磨回路），然后将这些作用与腹侧作用进行比较，来解决这个问题心脏神经元（VCN）机械感觉系统。在这里，我们显示，GPR神经元通过激活连合神经节中的两个已识别的投射神经元，调节性连合神经元1（MCN1）和连合投射神经元2（CPN2）来激活胃胃神经节（STG）的胃磨节律。该结论的支持来自调节性蛋白水解素神经元（MPN）的功能，该投射神经元通过其对MCN1和CPN2的抑制作用而抑制胃部节律，从而抑制GPR引起的胃部节律。选择性消除MCN1和CPN2对STG的访问也可以防止此节奏的GPR激活。 VCN神经元还通过共同激活MCN1和CPN2来激发胃部节律，但是GPR引起的胃部节律是不同的。这些截然不同的节奏可能部分是由于在这两种情况下MCN1活性水平不同，另一部分是STG中存在其他GPR作用。这些结果支持这样的假说：尽管不同的感觉系统对投射神经元的单个亚群具有收敛作用，但它们不同地调节神经元回路活动。

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