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首页> 外文期刊>The Journal of Neuroscience: The Official Journal of the Society for Neuroscience >Perirhinal cortex supports delay fear conditioning to rat ultrasonic social signals.
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Perirhinal cortex supports delay fear conditioning to rat ultrasonic social signals.

机译：周围神经皮层支持延迟对大鼠超声社交信号的恐惧调节。

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摘要

Auditory information can reach the lateral nucleus of the amygdala (LA) through a monosynaptic thalamic projection or a polysynaptic cortical route. The polymodal input from the perirhinal cortex (PR) is a major informational gateway to the LA and nearby structures. Pretraining PR lesions impair fear conditioning to a context, but there have been no reports that they cause deficits in delay conditioning to an auditory cue. The direct subcortical projection to the LA seems sufficient to support delay conditioning to a tone conditional stimulus (CS). We examined the effect of PR lesions on delay conditioning to two different tone conditional stimuli (4 and 22 kHz tones; both 10 sec duration) and two different rat ultrasonic vocalization (USV) conditional stimuli (10 sec of 22 kHz USVs that were recorded (digitized at 100 kHz) from two different rats. One USV CS was a continuous sequence of eight calls, and the other was a portion of a continuous sequence of six calls. PR lesions significantly impaired conditioning to both USV conditional stimuli and to the training context but had no significant effect on conditioning to either tone CS. The role of PR in fear conditioning appears not to be determined by whether the conditional stimuli serve as contexts or cues, but instead by the nature or complexity of the stimuli or stimulus configurations. These cue-specific effects of PR lesions are suggested to reflect differences in the stimulus features that are encoded in the two CS pathways to the LA.
机译：听觉信息可通过单突触丘脑投射或多突触皮质途径到达杏仁核（LA）的外侧核。来自周围神经皮层（PR）的多峰输入是通往LA及其附近结构的主要信息门户。训练前的PR病变会在某种程度上削弱恐惧感，但是没有报道表明它们会导致听觉提示的延迟适应能力下降。皮层下直接投射到LA似乎足以支持对声调条件刺激（CS）的延迟调节。我们检查了PR病变对两种不同音调条件刺激（4和22 kHz音调;均持续10秒）和两种不同大鼠超声发声（USV）条件刺激（记录10 sec的22 kHz USV延迟调节）的影响（从两只不同的大鼠以100 kHz的频率数字化），一个USV CS是连续8个呼出序列，另一只是连续6个呼出序列的一部分PR病变显着削弱了USV条件刺激和训练环境的调节PR对恐惧调节的作用似乎不是由条件刺激是作为情境还是线索来确定，而是由刺激或刺激结构的性质或复杂性来决定。建议对PR病变进行提示特异性作用，以反映在通往LA的两个CS路径中编码的刺激特征的差异。

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