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首页> 外文期刊>The Journal of Neuroscience: The Official Journal of the Society for Neuroscience >Three-dimensional organization of the recurrent axon collateral network of the substantia nigra pars reticulata neurons in the rat.
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Three-dimensional organization of the recurrent axon collateral network of the substantia nigra pars reticulata neurons in the rat.

机译：大鼠黑质网状神经元的复发性轴突侧支网络的三维组织。

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摘要

The substantia nigra pars reticulata (SNR) constitutes a major output nucleus of the basal ganglia where the final stage of information processing within this system takes place. In this study, using juxtacellular labeling and three-dimensional reconstruction methods, we investigated the spatial organization of the intranigral innervation provided by single GABAergic projection neurons from the sensory-motor subdivision of the rat SNR. Confirming previous observations, most labeled SNR cells were found to possess a local axonal network innervating the pars reticulata and pars compacta (SNC). Within the SNR, axons of these cells were distributed along curved laminas enveloping a dorsolaterally located core, thus mostly respecting the onion-like compartmentalization of this nucleus. Although the axonal projection field mostly remained confined to the dendritic field of the parent neuron, it usually extended beyond its limits in caudal, lateral, and/or dorsal directions. Because SNR cells are GABAergic, this pattern of axonal projection suggests the existence of lateral inhibitory interactions between neurons belonging to the same as well as to adjacent functional subdivisions. Axonal projections of SNR cells to the SNC formed longitudinal bands. These bands partly occupied the SNC region projecting to the striatal sector from which parent SNR cells receive their afferents. These data indicate that SNR cells contribute to an indirect nigrostriatal loop circuit through which the striatum could upregulate its level of dopaminergic transmission via a disinhibition of nigrostriatal neurons. Spatial relationships between elements of this indirect nigrostriatonigral circuit indicate that this circuit operates in both a closed and open loop manner.
机译：黑质网状结构（SNR）构成了基底神经节的主要输出核，该系统中信息处理的最后阶段发生在该基底核。在这项研究中，使用并列细胞标记和三维重建方法，我们调查了来自大鼠SNR感觉运动细分的单个GABA能投射神经元提供的神经内支配位的空间组织。证实了先前的观察结果，发现大多数标记的SNR细胞都具有神经轴突网络，该神经轴突网络支配网状和致密性（SNC）。在SNR范围内，这些细胞的轴突沿着弯曲的椎板分布，这些弯曲的椎板包围着背外侧的核，因此主要考虑了该核的洋葱状分隔。尽管轴突投影场大多局限于亲本神经元的树突场，但它通常在尾，侧和/或背方向上延伸超过其极限。因为SNR细胞是GABA能的，所以这种轴突投射模式表明，属于同一神经元以及相邻功能区的神经元之间存在侧向抑制性相互作用。 SNR信元到SNC的轴突投影形成纵向带。这些频带部分占据了SNC区域，投射到纹状体，母SNR信元从该纹状体接收传入信号。这些数据表明，SNR细胞有助于间接纹状体纹状体回路，纹状体可以通过抑制纹状体纹状体神经元来上调其多巴胺能传递水平。该间接黑纹状体-​​三角神经回路的元件之间的空间关系表明该回路以闭环和开环方式工作。

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