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Long-term depression at olfactory nerve synapses.

机译:嗅神经突触的长期抑郁。

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摘要

The synapses formed by the olfactory nerve (ON) convey sensory information to olfactory glomeruli, the first stage of central odor processing. Morphological and behavioral studies suggest that glomerular odor processing is plastic in neonate rodents. However, long-term synaptic plasticity, a cellular correlate of functional and structural plasticity, has not yet been demonstrated in this system. Here, we report that ON-->mitral cell (MC) synapses of 5- to 8-d-old mice express long-term depression (LTD) after brief low-frequency ON stimulation. Pharmacological techniques and imaging of presynaptic calcium signals demonstrate that ON-MC LTD is expressed presynaptically and requires the activation of metabotropic glutamate receptors but does not require fast synaptic transmission. LTD at the ON--> MC synapse is potentially relevant for the establishment, maintenance, and experience-dependent refinement of odor maps in the olfactory bulb.
机译:嗅觉神经(ON)形成的突触将感觉信息传递到嗅觉肾小球,这是中央气味处理的第一阶段。形态和行为研究表明,新生啮齿类动物的肾小球气味处理是可塑性的。但是,长期突触可塑性,功能和结构可塑性的细胞相关,尚未在该系统中得到证明。在此,我们报道了短暂的低频ON刺激后,5至8日龄小鼠的ON->质膜细胞(MC)突触表达了长期抑郁(LTD)。药理学技术和突触前钙信号的成像表明,ON-MC LTD是突触前表达的,需要激活代谢型谷氨酸受体,但不需要快速的突触传递。 ON-> MC突触上的LTD与嗅球中气味图的建立,维护和依赖经验的提炼潜在相关。

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