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首页> 外文期刊>The Journal of Neuroscience: The Official Journal of the Society for Neuroscience >Dopamine is a regulator of arousal in the fruit fly.
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Dopamine is a regulator of arousal in the fruit fly.

机译：多巴胺是果蝇中唤醒的调节剂。

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摘要

Sleep and arousal are known to be regulated by both homeostatic and circadian processes, but the underlying molecular mechanisms are not well understood. It has been reported that the Drosophila rest/activity cycle has features in common with the mammalian sleep/wake cycle, and it is expected that use of the fly genetic model will facilitate a molecular understanding of sleep and arousal. Here, we report the phenotypic characterization of a Drosophila rest/activity mutant known as fumin (fmn). We show that fmn mutants have abnormally high levels of activity and reduced rest (sleep); genetic mapping, molecular analyses, and phenotypic rescue experiments demonstrate that these phenotypes result from mutation of the Drosophila dopamine transporter gene. Consistent with the rest phenotype, fmn mutants show enhanced sensitivity to mechanical stimuli and a prolonged arousal once active, indicating a decreased arousal threshold. Strikingly,fmn mutants do not show significant rebound in response to rest deprivation as is typical for wild-type flies, nor do they show decreased life span. These results provide direct evidence that dopaminergic signaling has a critical function in the regulation of insect arousal.
机译：众所周知，睡眠和唤醒受体内稳态和昼夜节律过程的调节，但其潜在的分子机制尚不清楚。据报道，果蝇的休息/活动周期具有与哺乳动物的睡眠/觉醒周期相同的特征，并且预期飞行遗传模型的使用将促进对睡眠和唤醒的分子理解。在这里，我们报告果蝇休息/活动突变称为富民（fmn）的表型表征。我们表明，fmn突变体具有异常高水平的活动和减少的休息（睡眠）;遗传作图，分子分析和表型抢救实验表明，这些表型是果蝇多巴胺转运蛋白基因突变的结果。与其余表型一致，fmn突变体显示出对机械刺激的敏感性增强，并且一旦激活就具有较长的唤醒，表明唤醒阈值降低。引人注目的是，fmn突变体没有表现出对野生动物苍蝇典型的对休息剥夺的显着反弹，也没有显示寿命缩短。这些结果提供了直接的证据，表明多巴胺能信号传导在调节昆虫唤醒中起关键作用。

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