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首页> 外文期刊>The Journal of Neuroscience: The Official Journal of the Society for Neuroscience >Dopamine D1 receptors synergize with D2, but not D3 or D4, receptors in the striatum without the involvement of action potentials.
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Dopamine D1 receptors synergize with D2, but not D3 or D4, receptors in the striatum without the involvement of action potentials.

机译：多巴胺D1受体与纹状体中的D2受体协同作用，但不与D3或D4受体协同作用，而没有动作电位的参与。

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摘要

The widespread biological actions of the neurotransmitter dopamine (DA) are mediated by two classes of receptor, the D(1) class (D(1) and D(5)) and the D(2) class (D(2), D(3), and D(4)), which interact synergistically in many paradigms, such as DA agonist-stimulated motor behavior and striatal c-fos expression. Understanding the mechanism(s) of this interaction has been impeded by a controversy regarding the cellular localization of D(1) and D(2) class receptors. To address this issue from a functional point of view, we elicited striatal Fos by combined administration of a D(1) class and a D(2) class agonist either in the presence or absence of the fast sodium channel blocker tetrodotoxin (TTX). Striatal Fos elicited by direct D(1)/D(2) stimulation was not reduced by TTX. By contrast, TTX greatly attenuated the Fos response evoked by cocaine or GBR 12909. In separate experiments using antagonists that distinguish among members of the D(2) class of receptors, amphetamine-stimulated Fos and motor behavior were attenuated dose-dependently by the selective D(2) antagonist L-741,626, but not by the selective D(3) antagonist U99194A or the D(4)-selective antagonist L-745,870. Because Fos expression in the paradigms that were used occurs in enkephalin-negative striatonigral neurons, which show limited coexpression of D(1) and D(2) receptors, the present findings taken together suggest the intriguing possibility that D(1)/D(2) synergism may be mediated by D(1) and D(2) receptors residing on separate striatal neurons and interacting in a manner that is not dependent on action potentials.
机译：神经递质多巴胺（DA）的广泛的生物学作用是由两类受体介导的，即D（1）类（D（1）和D（5））和D（2）类（D（2），D （3）和D（4）），它们在许多范式中协同相互作用，例如DA激动剂刺激的运动行为和纹状体c-fos表达。有关D（1）和D（2）类受体的细胞定位的争论已阻碍了对这种相互作用机制的理解。为了从功能的角度解决此问题，我们通过在存在或不存在快速钠通道阻滞剂河豚毒素（TTX）的情况下联合施用D（1）类和D（2）类激动剂来诱发纹状体Fos。 TTX不会减少直接D（1）/ D（2）刺激引起的纹状体Fos。相比之下，TTX大大减弱了可卡因或GBR 12909引起的Fos反应。在单独的使用区分D（2）类受体成员的拮抗剂的实验中，苯丙胺刺激的Fos和运动行为通过选择性的剂量依赖性减弱。 D（2）拮抗剂L-741,626，但不是由选择性D（3）拮抗剂U99194A或D（4）选择性拮抗剂L-745,870所致。因为在所使用的范例中Fos表达发生在脑啡肽阴性的纹状体神经元中，这表明D（1）和D（2）受体的共表达有限，所以目前的发现共同表明D（1）/ D（ 2）协同作用可能由位于单独的纹状体神经元上的D（1）和D（2）受体介导，并且以不依赖于动作电位的方式相互作用。

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