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Prognostic value of circulating cytokines on overall survival and disease-free survival in cancer patients

机译：循环细胞因子对癌症患者总体生存和无病生存的预后价值

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Through their tumor-promoting and/or tumor-suppressive properties, cytokines can influence progression of cancer. We systematically reviewed the current literature on the prognostic value of the circulating cytokines IL-1α/, IL-6, IL-8, IL-10, IL-12, TNF-α, TGF- and IFN- to predict overall and disease-free survival in any type of cancer patients. PubMed was systematically searched and based on eligibility assessment using our five criteria of the Reporting Recommendations for Tumor Marker Prognostic Studies (REMARK) checklist, six unique studies were reviewed. Elevated IL-6 and IL-10 levels seem independently associated with worse prognosis in terms of overall and disease-free survival. The prognostic value of IL-1α/, IL-8, IL-12, TNF-α, TGF- and IFN- could not be demonstrated. The small number of selected studies underlines the need for large well-designed prospective studies, using the REMARK checklist as a guideline, to determine which cytokines have prognostic value on survival in cancer patients.
机译：通过其促进肿瘤和/或抑制肿瘤的特性，细胞因子可以影响癌症的进展。我们系统地回顾了有关循环细胞因子IL-1α/，IL-6，IL-8，IL-10，IL-12，TNF-α，TGF-和IFN-的预后价值的当前文献，以预测总体和疾病-任何类型的癌症患者的免费生存。系统地搜索了PubMed，并根据合格性评估，使用我们的《肿瘤标志物预后研究报告建议》（REMARK）检查清单的五项标准对六项独特的研究进行了回顾。就总体和无病生存而言，升高的IL-6和IL-10水平似乎与预后不良相关。无法证明IL-1α/，IL-8，IL-12，TNF-α，TGF-和IFN-的预后价值。少数选定的研究强调需要使用REMARK清单作为指南来进行精心设计的大型前瞻性研究，以确定哪些细胞因子对癌症患者的生存具有预后价值。

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