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首页> 外文期刊>The Journal of Neuroscience: The Official Journal of the Society for Neuroscience >Repeated cocaine augments excitatory amino acid transmission in the nucleus accumbens only in rats having developed behavioral sensitization.
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Repeated cocaine augments excitatory amino acid transmission in the nucleus accumbens only in rats having developed behavioral sensitization.

机译：重复的可卡因仅在已表现出行为敏化的大鼠中增强伏隔核中的兴奋性氨基酸传递。

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Rats were pretreated with daily cocaine or saline injections for 1 week. The rats treated with daily cocaine were separated into two groups: a sensitized group of animals demonstrating > 20% increase in motor activity on the last injection compared with the first injection of daily cocaine, and a nonsensitized group showing < 20% elevation. At 2-3 weeks after the last daily injection, four experiments were performed to assess changes in excitatory amino acid (EAA) transmission in the nucleus accumbens produced by repeated cocaine administration. (1) Rats were challenged with a microinjection of AMPA into the shell or core of the nucleus accumbens. The sensitized rats demonstrated greater motor activity than did the saline-pretreated or nonsensitized animals after AMPA injection into either subnucleus. (2) It was shown that the behavioral distinction between sensitized, nonsensitized, and control rats in behavioral responsiveness to AMPA was not mediated by differences in AMPA-induced dopamine release. (3) The extracellular content of glutamate was measured after a cocaine challenge given at 21 d of withdrawal. Cocaine elevated the levels of glutamate in the core of sensitized rats, but not of nonsensitized or control rats. (4) Microinjection of the non-NMDA antagonist 6-cyano-7-nitroquinoxaline-2,3-dione into the core abolished the augmented motor response to a cocaine challenge in sensitized rats, but was without effect on cocaine-induced motor activity in nonsensitized animals. These results indicate that repeated cocaine administration increases EAA transmission in the nucleus accumbens only in rats that develop behavioral sensitization to cocaine.
机译：每天用可卡因或盐水注射预处理大鼠1周。每天用可卡因治疗的大鼠分为两组：致敏组的动物在最后一次注射中的运动能力比首次注射可卡因高出20％，而未敏化的动物则显示了<20％的升高。在最后一次每日注射后的2-3周，进行了四个实验，以评估通过重复给予可卡因而产生的伏隔核中兴奋性氨基酸（EAA）传递的变化。 （1）将AMPA显微注射到伏隔核的壳或核中攻击大鼠。在将AMPA注入任一亚核后，致敏的大鼠表现出比经盐水处理或未致敏的动物更大的运动活性。 （2）研究表明，敏化，非敏化和对照大鼠在对AMPA的行为反应方面的行为差异不是由AMPA诱导的多巴胺释放差异来介导的。 （3）在戒断第21天给予可卡因攻击后，测量谷氨酸的细胞外含量。可卡因提高了致敏大鼠核心的谷氨酸水平，但没有致敏大鼠或对照大鼠的核心。 （4）将非NMDA拮抗剂6-氰基-7-硝基喹喔啉-2,3-二酮微注射到核中可消除致敏大鼠对可卡因攻击的增强运动反应，但对可卡因诱导的运动活性无影响不敏感的动物。这些结果表明，仅在对可卡因产生行为敏感性的大鼠中，重复施用可卡因可增加伏安核中的EAA传递。

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