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首页> 外文期刊>The Annals of otology, rhinology, and laryngology >Histologic study of perifascial areolar tissue implanted in rabbit vocal folds: an experimental study.
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Histologic study of perifascial areolar tissue implanted in rabbit vocal folds: an experimental study.

机译：兔声带植入筋膜周围乳晕组织的组织学研究：一项实验研究。

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OBJECTIVES: Perifascial areolar tissue (PAT) consists of loose areolar tissue with viscoelastic properties that are similar to those found in tissues in the superficial layer of the vocal fold. The aim of this study was to quantify the inflammatory process and the collagen content of the graft, as well as that of the host tissue, after placement of a strip of PAT into the rabbit vocal fold. METHODS: Surgeries were performed on 30 rabbits. The grafts were implanted in pockets that were surgically created in the right vocal fold. The left vocal fold (control group) was subjected only to surgical manipulation. The animals were divided into 3 groups for evaluations at 15 days, 3 months, and 6 months, and their larynx tissues were subsequently reviewed by histology. RESULTS: The grafts were characterized by disorganized and thick collagen bundles and were identified in all study groups. The collagen density stayed constant over time. There was an acute inflammatory response induced by the graft at 15 days that did not exist in the specimens taken at 3 and 6 months. Deposition of collagen fibers in the lamina propria was observed starting at 15 days after the operation and was more intense in the experimental vocal fold than in the control vocal fold. CONCLUSIONS: Our findings indicated that PAT has a low tendency for promoting an inflammatory response. However, there was a loss of the original architecture of the graft tissue and a greater deposition of collagen in the implanted vocal folds than in the control group.
机译：目的：筋膜乳晕组织（PAT）由具有粘弹性的松散的乳晕组织组成，类似于声带表层组织中的粘弹性。这项研究的目的是在将一条PAT条放入兔的声带中后，量化炎症过程和移植物以及宿主组织的胶原蛋白含量。方法：对30只兔进行手术。将移植物植入手术中在右声带形成的口袋中。左声带（对照组）仅接受外科手术。在15天，3个月和6个月时将动物分为3组进行评估，随后通过组织学检查它们的喉组织。结果：移植物的特点是胶原束混乱且粗大，并且在所有研究组中均得到了鉴定。胶原密度随时间保持恒定。在第15天，移植物引起的急性炎症反应在3个月和6个月的标本中不存在。在手术后15天开始观察到固有层中胶原纤维的沉积，并且在实验声带中比在对照声带中更强烈。结论：我们的研究结果表明，PAT促进炎症反应的趋势较低。但是，与对照组相比，移植组织的原始结构丧失了，并且在植入的人声带中胶原蛋白的沉积更大。

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