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首页> 外文期刊>The Journal of pediatrics >Longitudinal relationship among growth, nutritional status, and pulmonary function in children with cystic fibrosis: analysis of the Cystic Fibrosis Foundation National CF Patient Registry.
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Longitudinal relationship among growth, nutritional status, and pulmonary function in children with cystic fibrosis: analysis of the Cystic Fibrosis Foundation National CF Patient Registry.

机译：囊性纤维化儿童的生长，营养状况和肺功能之间的纵向关系：囊性纤维化基金会国家CF患者注册中心的分析。

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OBJECTIVE: To determine prospectively the relationship among growth, nutritional status, and pulmonary function over a 4-year period in a large cohort of children with cystic fibrosis (CF). STUDY DESIGN: CF Foundation National CF Patient Registry data collected from 1991 to 1995 for 968 children (507 male) aged 5 to 8 years with pancreatic insufficiency and forced expiratory volume in 1 second within 60% to 140% of predicted values (FEV(1)%) were analyzed longitudinally. Variables hypothesized to affect FEV(1)% included age, sex, z scores for height, weight, percent of height-appropriate body weight, and annual number of days hospitalized. RESULTS: The significant decline in FEV(1)% was curvilinear and dependent on baseline FEV(1)%; children with initial FEV(1)% > or = 90 declined 2.6 U/y more than those with initial FEV(1)% <90. Boys gained but girls declined in z scores for height. Girls decreased in z scores for weight at a greater rate than boys. The z scores for weight and percent of height-appropriate body weight were significantly associated with longitudinal changes in FEV(1)%, after adjustment was done for hospitalizations. CONCLUSIONS: Growth, nutritional status, and pulmonary function are not stable in prepubertal children with CF and pancreatic insufficiency. Important sex-related differences in growth occur before puberty. Growth and nutritional status are associated with changes in FEV(1)%, suggesting that nutritional intervention may slow the decline in pulmonary function in children with CF.
机译：目的：前瞻性确定一大批囊性纤维化（CF）儿童在4年内的生长，营养状况和肺功能之间的关系。研究设计：CF基金会从1991年至1995年的国家CF患者注册数据收集了968例5至8岁的儿童（507男性），其胰腺功能不全且在1秒内用力呼气量在预测值的60％至140％之内（FEV（1 ）％）进行纵向分析。假设会影响FEV（1）％的变量包括年龄，性别，身高，体重的z得分，适合身高的体重百分比以及每年住院天数。结果：FEV（1）％的显着下降是曲线的，并且依赖于基线FEV（1）％。初始FEV（1）％>或= 90的儿童比初始FEV（1）％<90的儿童下降2.6 U / y。男孩的身高增长了，女孩的z得分却下降了。女孩的体重Z值下降幅度大于男孩。调整住院治疗后，体重和身高适当体重百分比的z得分与FEV（1）％的纵向变化显着相关。结论：青春期前患有CF和胰腺功能不全的儿童的生长，营养状况和肺功能不稳定。重要的与性别相关的生长差异发生在青春期之前。生长和营养状况与FEV（1）％的变化有关，这表明营养干预可减缓CF儿童的肺功能下降。

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