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首页> 外文期刊>The Journal of pharmacy technology: jPT : official publication of the Association of Pharmacy Technicians >Anaphylactic shock to oxaliplatin in the adjuvant context
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Anaphylactic shock to oxaliplatin in the adjuvant context

机译：在佐剂环境中对奥沙利铂的过敏性休克

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摘要

Objective: To report a case of anaphylactic shock in a patient receiving oxaliplatin treatment. Case Summary: A 60-year-old Chinese woman received adjuvant oxaliplatin in combination with fluorouracil and folinic acid for treatment of stage 3 colon cancer. Shortly after initiation of her 12th infusion, she developed anaphylactic shock. She has since fully recovered from the adverse drug event. She was not rechallenged with oxaliplatin. Discussion: Severe hypersensitivity reactions to oxaliplatin are rare. An objective causality assessment using the Naranjo probability scale revealed that an adverse drug reaction to oxaliplatin was highly probable. Based on the Common Terminology Criteria for Adverse Events version 3 for defining reaction severity, our patient had experienced a grade 4 reaction, or anaphylaxis. Conclusions: With more widespread use of oxaliplatin in the treatment of early stage as well as advanced disease, the potential for more instances of severe hypersensitivity reactions exists, although the percentage of grade 4 reactions will likely remain rare. The role of intradermal skin testing to predict oxaliplatin sensitivity and the implementation of oxaliplatin desensitization protocols in cases of severe hypersensitivity reactions to this drug in the adjuvant setting may be useful.
机译：目的：报告一例接受奥沙利铂治疗的过敏性休克患者。病例摘要：一名60岁的中国妇女接受奥沙利铂联合氟尿嘧啶和亚叶酸的辅助治疗3期结肠癌。开始第十二次输注后不久，她出现了过敏性休克。此后，她已从药物不良事件中完全康复。她没有接受过奥沙利铂的挑战。讨论：对奥沙利铂的严重超敏反应很少见。使用Naranjo概率量表进行的客观因果关系评估显示，对奥沙利铂产生不良药物反应的可能性很高。根据定义不良反应严重程度的《不良事件通用术语标准》第3版，我们的患者经历了4级反应或过敏反应。结论：随着奥沙利铂在早期和晚期疾病中的广泛使用，尽管发生4级反应的百分比仍然很少，但存在更多发生严重超敏反应的可能性。在佐剂环境中对该药物发生严重超敏反应的情况下，皮内皮肤测试对预测奥沙利铂敏感性的作用和奥沙利铂脱敏方案的实施可能是有用的。

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