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首页> 外文期刊>The Journal of pharmacy technology: jPT : official publication of the Association of Pharmacy Technicians >Rabbit Syndrome Likely Induced by Escitalopram: A Case Report
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Rabbit Syndrome Likely Induced by Escitalopram: A Case Report

机译：艾司西酞普兰可能诱发兔综合征：一例报告

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Objective: As reports of rabbit syndrome (RS) unrelated to antipsychotic medications have appeared, antidepressants, especially serotonin reuptake inhibitors (SSRJs), have been pointed as offenders producing RS. The induction of RS by SSRIs has been thought to be a consequence of serotonergically mediated inhibition of the dopaminergic system. We present a case of escitalopram-induced RS to increase awareness of this problem. Case Summary: A 35-year-old male, diagnosed with moderate depressive disorder, was started on escitalopram 10 mg/day along with clonazepam 0.5 mg at night on an outpatient basis. Personal and family history was not significant for any medical or psychiatric disorder, including movement disorders. Results: Three months after the initiation of escitalopram, the patient started complaining of abnormal trembling perioral movements, which increased on tasks involving focusing. A computed tomography scan of the brain revealed normal findings. With a diagnosis of drug-induced RS, escitalopram was stopped and 2 mg/day trihexyphenidyl was started. The patient reported complete improvement in 20 days. Trihexyphenidyl was stopped and sodium valproate 400 mg was started for irritability. Conclusions: Escitalopram can induce RS. This effect suggests that, for some patients, escitalopram has neuropsychiatric effects similar to those of a dopamine-blocking antipsychotic drug. Besides stopping medication, some patients may require medications temporarily to relieve symptoms.
机译：目的：由于出现了与抗精神病药物无关的兔症候群（RS）的报告，抗抑郁药，特别是血清素再摄取抑制剂（SSRJs）被认为是产生RS的罪犯。 SSRI诱导RS的诱导被认为是血清素介导的多巴胺能系统抑制的结果。我们提出一例依西酞普兰诱导的RS，以提高对此问题的认识。病例摘要：一名诊断为中度抑郁症的35岁男性，在门诊就开始服用依他普仑10毫克/天和氯硝西am 0.5毫克/天。个人和家族史对任何医学或精神病（包括运动障碍）均不重要。结果：艾司西酞普兰治疗开始三个月后，患者开始抱怨口腔周围颤动异常，增加了涉及聚焦的任务。大脑的计算机断层扫描显示正常结果。诊断为药物诱发的RS后，停止使用依他普仑并开始2 mg / day的三己基哌啶基。患者报告在20天内完全好转。停止使用三己基苯​​基，并开始服用400 mg丙戊酸钠以引起烦躁。结论：艾司西酞普兰可诱导RS。这种作用表明，对于某些患者来说，依他普仑具有与阻断多巴胺的抗精神病药相似的神经精神作用。除了停止药物治疗外，有些患者可能会暂时需要药物治疗以缓解症状。

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