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首页> 外文期刊>The Journal of pharmacy technology: jPT : official publication of the Association of Pharmacy Technicians >lime Required by Pharmacy Technicians to Reconstitute New versus Old PiperaciUin/Tazobactam Formulations
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lime Required by Pharmacy Technicians to Reconstitute New versus Old PiperaciUin/Tazobactam Formulations

机译：药房的技术人员需要用石灰来配制新的与旧的哌拉西汀/他唑巴坦制剂

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Background: Piperacillin/tazobactam, an intravenous broad-spectrum antibiotic commonly used in the hospital setting, has recently been reformulated with edetate disodium dehydrate (EDTA) and sodium citrate due to new guidelines on particulate standards. This reformulation is now compatible with lactated Ringer's solution and certain aminoglycosides. Objective: To determine the time required for pharmacy technicians to reconstitute the reformulated piperacillin/tazobactam solution compared with the original and European (Vial X) formulations. Methods: This study was conducted in an intravenous preparation room using a time-motion design. Each of 5 pharmacy technicians, who were blinded to the formulation, repeated the reconstitution process 6 times for a total of 30 observations of each strength within each formulation. Each piperacillin/tazobactam vial was reconstituted individually. Labor costs were calculated using the 2005 US hourly wage for pharmacy technicians. Results: Reconstitution times did not differ between formulations for the 3.375 g vial (mean ?SE, 4.15 + 0.26 min for original vs 4.92 + 0.58 min for EDTA formulations; p = 0.112). However, formulations containing EDTA went into solution more rapidly at the 4.5 g strength (4.41 + 0.33 min vs 6.79 + 0.61 min; p < 0.001) and did not differ from the Vial X formulation (4.12 ?0.23 min; p = 0.781). The large 40.5 g pharmacy bulk vial was tested only with the EDTA formulation, which required 5.58 + 0.41 minutes to reconstitute. Conclusions: Based on these timings, the labor costs associated with reconstituting a single vial of each strength is approximately dollar1 per vial, regardless of which formulation is used. Reformulated piperacillin/tazobactam containing EDTA and sodium citrate will go into solution at least as quickly as the original formulation.
机译：背景：哌拉西林/他唑巴坦（一种普遍用于医院的静脉内广谱抗生素）最近由于颗粒物标准的新指导方针，被乙二胺四乙酸二钠脱水钠（EDTA）和柠檬酸钠重新配制。现在，这种重新配制与乳酸林格氏液和某些氨基糖苷兼容。目的：确定与原始配方和欧洲（Vial X）配方相比，药房技术人员重构重新配制的哌拉西林/他唑巴坦溶液所需的时间。方法：本研究在时空设计的静脉准备室中进行。对制剂不了解的5名药学技术人员中的每一个，都对重构过程重复了6次，每次对每种制剂中的每种强度进行了30次观察。将每个哌拉西林/他唑巴坦小瓶分别重构。人工成本是根据2005年美国药房技术人员的每小时工资计算得出的。结果：对于3.375 g的小瓶，两种制剂的重构时间没有差异（平均值为-SE，原始溶液为4.15 + 0.26分钟，而EDTA制剂为4.92 + 0.58分钟; p = 0.112）。但是，含EDTA的制剂以4.5 g的强度（4.41 + 0.33分钟vs. 6.79 + 0.61分钟; p <0.001）更快地溶解，与Vial X制剂（4.12〜0.23分钟; p = 0.781）没有区别。仅使用EDTA制剂测试了40.5 g的大药房散装小瓶，这需要5.58 + 0.41分钟来进行重构。结论：根据这些时间安排，与使用每种强度的单个小瓶进行重构相关的人工成本约为每小瓶1美元，而与使用哪种配方无关。含有EDTA和柠檬酸钠的重新配制的哌拉西林/他唑巴坦将至少与原始制剂一样快地进入溶液。

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