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首页> 外文期刊>The Journal of pharmacy technology: jPT : official publication of the Association of Pharmacy Technicians >A Comparison of Event Rates for Patients Receiving Sirolimus Drug-Eluting vs. Bare Metal Stents
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A Comparison of Event Rates for Patients Receiving Sirolimus Drug-Eluting vs. Bare Metal Stents

机译：西罗莫司药物洗脱患者与裸金属支架患者事件发生率的比较

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Background: Two types of stents are used to revascularize occluded coronary arteries. Bare metal stents prevent elastic recoil and negative remodeling of the vessel wall following balloon catheter stretch. Drug-eluting stents release medications that prevent the development of neointimal hyperplasia. Drug-eluting stents, however, have been purported to increase the risk of acute stent thrombosis, potentially placing patients at higher risk for major adverse cardiac events in the 12 months following stent implementation.Objective: To determine whether patients receiving a drug-eluting stent experienced a higher rate of major adverse cardiac events at one year after stent placement than did patients who received a bare metal stent, and to determine the impact of antiplatelet therapy on major adverse cardiac event rates.Methods: We conducted a retrospective chart review of patients receiving either a sirolimus-eluting or bare metal stent at the Veterans Affairs North Texas Health Care System between July and December 2003.Results: Sixty-eight patients were included in the study. There was one episode of acute stent thrombosis and no statistically significant difference in major adverse cardiac event rates at 1 year after stent placement between the groups. Clopidogrel therapy was originally prescribed for an average of 3.9 months in the drug-eluting stent group and I month in the bare metal stent group. The actual duration of clopidogrel therapy differed significantly from the original prescribed duration for both groups, mainly due to renewal of clopidogrel prescriptions by noncardiology practitioners.Conclusions: Patients who received a sirolimus-eluting stent did not experience an increase in major adverse cardiac events compared with patients receiving a bare metal stent.
机译：背景：两种类型的支架用于使闭塞的冠状动脉血运重建。裸金属支架可防止球囊导管拉伸后弹性回弹和血管壁的负面重塑。药物洗脱支架释放的药物可防止新内膜增生的发展。然而，据信药物洗脱支架会增加急性支架血栓形成的风险，可能使患者在实施支架后的12个月内有发生重大不良心脏事件的风险。目的：确定患者是否接受药物洗脱支架方法：我们进行了回顾性图表回顾，回顾了支架置入后一年发生的重大不良心脏事件发生率高于接受裸金属支架的患者的情况，并确定了抗血小板治疗对重大不良心脏事件发生率的影响。在2003年7月至12月间，在北德克萨斯州退伍军人事务部医疗系统接受了西罗莫司洗脱支架或裸机支架。结果：该研究纳入了68名患者。两组之间在放置支架后1年，发生了一次急性支架血栓形成事件，主要不良心脏事件发生率无统计学差异。最初规定在药物洗脱支架组中使用氯吡格雷治疗的平均时间为3.9个月，在裸金属支架组中的使用时间为1个月。两组氯吡格雷的实际疗程与最初规定的疗程有显着差异，这主要是由于非心脏病医生更新了氯吡格雷处方。结论：与使用西罗莫司洗脱支架相比，接受严重西药治疗的患者的主要不良心脏事件没有增加患者接受裸金属支架。

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