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首页> 外文期刊>Chromatographia >Chiral separation of chloroquine and pemoline by capillary zone electrophoresis with sulfobutyl ether beta-cyclodextrin as buffer additive
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Chiral separation of chloroquine and pemoline by capillary zone electrophoresis with sulfobutyl ether beta-cyclodextrin as buffer additive

机译：磺基丁基醚β-环糊精作为缓冲添加剂的毛细管区带电泳手性分离氯喹和匹莫林

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摘要

Cyclodextrin-mediated, capillary zone electrophoresis was used for the chiral separation of chloroquine and pemoline. Optimization experiments for the choice of cyclodextrins and the concentration of sulfobutyl ether beta-cyclodextrin were performed. Complete separations were obtained with a resolution of 2.1 for chloroquine in 2.5 mM sulfobutyl ether beta-cyclodextrin and a resolution of 1.4 for pemoline in 1.0 mM sulfobutyl ether beta-cyclodextrin, respectively, from which further biomedical research, such as pharmacodynamic or pharmacokinetic study and quantitative determination, could subsequently be facilitated. [References: 15]
机译：环糊精介导的毛细管区带电泳用于氯喹和匹莫林的手性分离。进行了环糊精的选择和磺丁基醚β-环糊精浓度的优化实验。获得了完全分离，分别在2.5 mM磺丁基醚β-环糊精中的氯喹分辨率为2.1，在1.0 mM磺丁基醚β-环糊精中的匹莫林分辨率为1.4。定量测定，随后可以方便进行。 [参考：15]

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