• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The Journal of Nutritional Biochemistry >Adipose triglyceride lipase expression and fasting regulation are differently affected by cold exposure in adipose tissues of lean and obese Zucker rats.
【24h】

Adipose triglyceride lipase expression and fasting regulation are differently affected by cold exposure in adipose tissues of lean and obese Zucker rats.

机译：肥胖和肥胖的Zucker大鼠脂肪组织中冷暴露对甘油三酸酯脂肪酶表达和禁食调节的影响不同。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Adipose triglyceride lipase (ATGL) hydrolyzes triacylglycerols to diacylglycerols in the first step of lipolysis, providing substrates for hormone-sensitive lipase (HSL). Here we studied whether ATGL messenger RNA (mRNA) and protein levels were affected by 24-h cold exposure in different white adipose tissue depots and in interscapular brown adipose tissue of lean and obese Zucker rats submitted to feeding and 14-h fasting conditions. HSL mRNA expression was also studied in selected depots. In both lean and obese rats, as a general trend, cold exposure increased ATGL mRNA and protein levels in the different adipose depots, except in the brown adipose tissue of lean animals, where a decrease was observed. In lean rats, cold exposure strongly improved fasting up-regulation of ATGL expression in all the adipose depots. Moreover, in response to fasting, in cold-exposed lean rats, there was a stronger positive correlation between circulating nonesterified fatty acids (NEFA) and ATGL mRNA levels in the adipose depots and a higher percentage increase of circulating NEFA in comparison with control animals not exposed to cold. In obese rats, fasting-induced up-regulation of ATGL was impaired and was not improved by cold. The effects of obesity and cold exposure on HSL mRNA expression were similar to those observed for ATGL, suggesting common regulatory mechanisms for both proteins. Thus, cold exposure increases ATGL expression and improves its fasting-up-regulation in adipose tissue of lean rats. In obese rats, cold exposure also increases ATGL expression but fails to improve its regulation by fasting, which could contribute to the increased difficulty for mobilizing lipids in these animals
机译：在脂解的第一步中，甘油三酸酯脂肪酶（ATGL）将三酰基甘油水解为二酰基甘油，为激素敏感性脂肪酶（HSL）提供底物。在这里，我们研究了在不同的白色脂肪组织贮藏库中以及瘦弱和肥胖的Zucker大鼠的肩cap间褐色脂肪组织中，在服食和禁食14小时后，ATGL信使RNA（mRNA）和蛋白质水平是否受到24小时冷暴露的影响。 HSL mRNA表达也在选定的库中进行了研究。在瘦鼠和肥胖大鼠中，一般趋势是，冷饮会增加不同脂肪库中ATGL mRNA和蛋白质的水平，除了在瘦肉动物的棕色脂肪组织中，这种现象有所减少。在瘦大鼠中，冷暴露在所有脂肪库中均能显着改善空腹ATGL表达的空腹上调。此外，响应禁食，在冷暴露的瘦大鼠中，与非对照动物相比，脂肪库中循环非酯化脂肪酸（NEFA）和ATGL mRNA水平之间存在更强的正相关关系，循环NEFA的百分比增加较高。暴露在寒冷中。在肥胖大鼠中，空腹诱导的ATGL上调受到损害，感冒并没有改善。肥胖和冷暴露对HSL mRNA表达的影响与ATGL相似，表明这两种蛋白具有共同的调控机制。因此，冷暴露增加了瘦大鼠脂肪组织中ATGL的表达并改善了其空腹调节。在肥胖大鼠中，冷暴露也会增加ATGL的表达，但不能通过禁食改善其调节，这可能导致这些动物动员脂质的难度增加

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号