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首页> 外文期刊>The Journal of Nutritional Biochemistry >Age and sex affect protein metabolism at protein intakes that span the range of adequacy: comparison of leucine kinetics and nitrogen balance data.
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Age and sex affect protein metabolism at protein intakes that span the range of adequacy: comparison of leucine kinetics and nitrogen balance data.

机译：年龄和性别会影响蛋白质摄入量的蛋白质代谢，这些蛋白质摄入量跨越足够的范围：亮氨酸动力学和氮平衡数据的比较。

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摘要

Research suggests that changes in leucine oxidation (leuox) with feeding may reflect adult protein requirements. We evaluated this possibility by assessing the effects of age, sex, and different protein intakes on whole-body leucine kinetics and nitrogen balance. Thirty-four young (n = 18, 22-46 years) and old (n = 16, 63-81 years) men and women completed three 18-day trials with protein intakes of 0.50, 0.75 and 1.00 g protein.kg body weight--1.d--1. Fasting and fed-state leucine kinetics were quantified on day 12 of each trial using a primed, constant infusion of L-[1-13C]leucine. Protein requirement was estimated using classical nitrogen balance measurements and calculations. Leucine kinetics parameters were influenced by age and sex across all protein intakes. With feeding, leuox increased more in old vs. young adults. Independent of age, fasting and fed-state leuox were lower, and net leucine balance (fasting+fed-state) was higher in women vs. men. Among all subjects and protein intakes, nitrogen balance was correlated with fed-state leuox (r = 0.39), fed-state leucine balance (r = 0.60), net leucine balance (r = 0.49) and the change in leuox from the fasting to fed state (r = 0.49) (P < .05 for all results). At the highest protein intake, the change in leuox with feeding was inversely correlated with protein requirement (r = --0.39). These findings indicate that leucine kinetics, especially leuox, reflect nitrogen balance-based estimates of the need for dietary protein and generally support the view that protein requirement is comparable between young and old adults
机译：研究表明，摄食过程中亮氨酸氧化（leu ox ）的变化可能反映了成人蛋白质的需求。我们通过评估年龄，性别和不同蛋白质摄入量对全身亮氨酸动力学和氮平衡的影响来评估这种可能性。三十四名年轻人（n = 18、22-46岁）和年龄（n = 16、63-81岁）男女完成了三个18天试验，分别摄入蛋白质0.50、0.75和1.00 g蛋白质。 kg体重-1。 d -1 。在每个试验的第12天，使用灌注的，恒定的L- [1-13C]亮氨酸输注对空腹和进食状态的亮氨酸动力学进行定量。使用经典的氮平衡测量和计算方法估算蛋白质需求量。在所有蛋白质摄入中，亮氨酸动力学参数受年龄和性别的影响。进食后，老年成年人的leu ox 增加更多。与年龄无关，女性与男性的空腹和进食状态leu ox 较低，净亮氨酸平衡（空腹+进食状态）较高。在所有受试者和蛋白质摄入量中，氮平衡与饲喂状态的leu ox （r = 0.39），饲喂状态的亮氨酸平衡（r = 0.60），净亮氨酸平衡（r = 0.49）和从空腹状态到进食状态的leu ox 的变化（r = 0.49）（所有结果的P <0.05）。蛋白质摄入量最高时，leu ox 随饲喂量的变化与蛋白质需求量呈负相关（r = --0.39）。这些发现表明，亮氨酸动力学，尤其是leu ox ，反映了基于氮平衡的膳食蛋白质需求估计值，并普遍支持蛋白质需求在年轻人和老年人之间具有可比性的观点。

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