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首页> 外文期刊>The Journal of Nutritional Biochemistry >Effect of 6-month caloric restriction on Cu bound to ceruloplasmin in adult overweight subjects
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Effect of 6-month caloric restriction on Cu bound to ceruloplasmin in adult overweight subjects

机译：6个月热量限制对成人超重受试者铜结合铜蓝蛋白的影响

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摘要

In a randomized clinical trial of calorie restriction (CR), we demonstrated that important cardiovascular disease (CVD) biomarkers were favorably influenced by CR alone and in conjunction with physical exercise. The aim of this study was to examine the effects of CR with or without exercise on copper bound to ceruloplasmin (CuCp), a well-known biomarker for CVD, in overweight men and women enrolled in the CALERIE phase 1 study. Forty-six individuals were randomized to one of four groups for 6 months: control, healthy weight maintenance; CR, 25% CR from baseline energy requirements; CR+exercise, 12.5% CR and 12.5% through aerobic exercise; and low-calorie diet, low-calorie diet until 15% reduction in body weight followed by weight maintenance diet. CuCp was determined in fasting blood samples by a high-performance liquid chromatography inductively coupled plasma mass spectrometry methodology and compared with changes in body composition and markers of CVD.
机译：在卡路里限制（CR）的随机临床试验中，我们证明了重要的心血管疾病（CVD）生物标志物受CR单独或与体育锻炼相结合会受到有利影响。这项研究的目的是在参加CALERIE 1期研究的超重男性和女性中，检查运动或不运动对CR的影响，铜对铜蓝蛋白（CuCp）的结合是一种众所周知的CVD生物标志物。 46名患者随机分为4组之一，共6个月：对照组，健康体重维持; CR，比基准能量需求高25％; CR +运动，12.5％CR和有氧运动12.5％;和低热量饮食，低热量饮食直到体重减少15％，然后再进行体重维持饮食。通过高效液相色谱-电感耦合等离子体质谱法测定空腹血液样本中的CuCp，并将其与人体成分和CVD标记物的变化进行比较。

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