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首页> 外文期刊>The Journal of Nutritional Biochemistry >The effect of long-term lactobacilli (lactic acid bacteria) enteral treatment on the central nervous system of growing rats
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The effect of long-term lactobacilli (lactic acid bacteria) enteral treatment on the central nervous system of growing rats

机译：长期乳酸菌（乳酸菌）肠内治疗对成年大鼠中枢神经系统的影响

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The aim of this study was to explore the relationship between consumption of large doses of lactic acid bacteria (LAB) and the behaviour and brain morphobiochemistry of normal growing rats. Four groups of rats were treated with LAB cultures twice daily for 6 months. The control group received 1 ml of saline per treatment, while two experimental groups received 1 ml of living bacteria (Lactobacillus plantarum and Lactobacillus fermentum, respectively) and the remaining group received a heat-treated (inactivated) L. fermentum culture. After 2 and 6 months of treatment, respectively, eight animals from each group were sacrificed, and specimens were taken for further analyses. The behaviour of the rats was evaluated five times in an open-field test at monthly intervals throughout the study. Lactobacilli treatment for 2 months induced changes in the motoric behaviour of the rats. The concentration of the astrocytesoluble and filament glial fibrillary acidic protein (GFAP) decreased in the posterior part of the hemispheres, including the thalamus, hippocampus and cortex of the rats treated with L. fermentum. A greater decrease in filament GFAP (up to 50%) was shown in the group receiving the live form of L. fermentum. In contrast, the GFAP in the live L. plantarum-treated group increased, showing elevated levels of the soluble and filament forms of GFAP in the posterior part of the hemispheres. A 60-66% decrease in the amount of the astrocyte-specific Ca-binding protein S-100b was shown in the posterior parts of the hemispheres and in the hindbrain of rats given LAB for 2 months. Prolonged feeding with LAB for 4 months up to full adulthood led to a further decrease in astrocyte reaction, reflected as an additional decrease in the amount of soluble GFAP and locomotor activity in all experimental groups. The changes in filament GFAP and S-100b appeared to disappear after prolonged feeding (total of 6 months) with LAB. In summary, LAB dietary treatment affected the ontogenetic development of the astrocytes, with the highest intensity observed in the early stages of rat development. It can be postulated that LAB treatment may play a preventive role in neurological diseases by decreasing astrocyte reaction and, consequently, lowering locomotor activity.
机译：这项研究的目的是探讨大剂量乳酸菌（LAB）的消耗与正常生长大鼠的行为和脑形态生物化学之间的关系。四组大鼠每天用LAB培养液治疗两次，持续6个月。对照组每次处理接受1 ml生理盐水，而两个实验组接受1 ml活细菌（分别为植物乳杆菌和发酵乳杆菌），其余组接受经过热处理（灭活）的发酵乳杆菌培养物。在分别治疗2个月和6个月后，将每组的8只动物处死，并取样进行进一步分析。在整个研究中，以每月一次的间隔在野外试验中对大鼠的行为进行五次评估。乳酸杆菌治疗2个月可诱发大鼠运动行为的变化。在发酵乳杆菌处理的大鼠的半球后部，包括丘脑，海马和皮层，星形胶质细胞可溶性和丝状胶质纤维酸性蛋白（GFAP）的浓度降低。接受活发酵乳杆菌的组中，细丝GFAP下降幅度更大（最高50％）。相反，活的植物乳杆菌处理组中的GFAP增加，显示半球后部GFAP的可溶性和丝状形式水平升高。在接受LAB治疗2个月的大鼠的半球后部和后脑中，星形胶质细胞特异性Ca结合蛋白S-100b的量减少了60-66％。 LAB持续喂养4个月直至成年，导致星形胶质细胞反应进一步降低，这反映为所有实验组中可溶性GFAP的含量和运动能力的进一步降低。长期喂食LAB（共6个月）后，细丝GFAP和S-100b的变化似乎消失了。总之，LAB饮食治疗影响星形胶质细胞的个体发育，在大鼠发育的早期阶段观察到强度最高。可以推测，LAB疗法可能通过减少星形胶质细胞反应并因此降低运动活性而在神经系统疾病中起到预防作用。

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