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首页> 外文期刊>The journal of obstetrics and gynaecology research >Diabetes mellitus and abnormalities in semen analysis
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Diabetes mellitus and abnormalities in semen analysis

机译：糖尿病与精液分析异常

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Aim: The aim of this study was to compare the semen parameters of diabetic husbands of infertile couples with those of non-diabetic husbands of proven fertility. Material and Methods: Assuming a 5% fall in DNA integrity of sperms would affect fertility, the required sample size calculated was 103, with 80% power and 5% level of significance. During the study period (January 2010 to May 2012), 52 husbands were found to have diabetes mellitus, by 2-h/post 75 g of glucose load (≥200 mg %). Glycosylated hemoglobin level in each case was found to be more than 6.5% (study group). During the same period, six couples with infertility conceived spontaneously while undergoing evaluations, 60 couples conceived following treatment of ovulatory disorders in wives and all had ongoing pregnancies (more than 12 weeks). Husbands of these 66 couples were found to be non-diabetic (control group). Conventional semen analysis (World Health Organization criteria), hypo-osmotic swelling test and DNA integrity test (Acridine Orange test) were done in all cases. Body mass index was measured in each case. Results: There were no differences in the mean age and body mass index between the two groups but significant differences were found in the following parameters: volume of the ejaculate (P = 0.004); total cells per ejaculate (P = 0.01); percent motility (P = 0.0001); total motile cells per ejaculate (P = 0.0001); percent of rapid progressive motility (P = 0.0001); percent normal morphology (P = 0.02); percent hypo-osmotic swelling test (0.0001); and percent normal DNA integrity (P = 0.0001). Conclusion: Diabetes mellitus can affect spermatogenesis at various levels, which can cause male-factor infertility.
机译：目的：本研究的目的是比较不育夫妇的糖尿病丈夫和已证实具有生育能力的非糖尿病丈夫的精液参数。材料和方法：假设精子的DNA完整性下降5％将影响生育力，则计算出的所需样本量为103，功效为80％，显着性水平为5％。在研究期间（2010年1月至2012年5月），在75克葡萄糖负荷（≥200 mg％）的作用下2小时/后，发现52名丈夫患有糖尿病。发现每种情况下糖基化血红蛋白水平均超过6.5％（研究组）。在同一时期，有6对夫妇在进行评估时自发地受孕，其中60对夫妇在治疗了妻子的排卵障碍后受孕，所有夫妇都在持续怀孕（超过12周）。这66对夫妇的丈夫被发现非糖尿病（对照组）。所有病例均进行常规精液分析（世界卫生组织标准），低渗溶胀试验和DNA完整性试验（A啶橙试验）。分别测量体重指数。结果：两组的平均年龄和体重指数无差异，但在以下参数上存在显着差异：射精量（P = 0.004）;射精量（P = 0.004）。每次射精的总细胞数（P = 0.01）;运动百分比（P = 0.0001）;每次射精的总运动细胞（P = 0.0001）;快速进行性运动的百分比（P = 0.0001）;正常形态百分比（P = 0.02）;低渗溶胀试验百分比（0.0001）;正常DNA完整性百分比（P = 0.0001）。结论：糖尿病可以不同程度影响精子发生，可引起男性不育症。

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